Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4371332..4371986 Replicon chromosome
Accession NZ_CP041511
Organism Shigella sonnei strain KCCM 41282

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag FNA55_RS22270 Protein ID WP_000244777.1
Coordinates 4371332..4371739 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FNA55_RS22275 Protein ID WP_000354046.1
Coordinates 4371720..4371986 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA55_RS22250 (4367289) 4367289..4369022 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
FNA55_RS22255 (4369028) 4369028..4369738 - 711 WP_140046308.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FNA55_RS22260 (4369763) 4369763..4370659 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FNA55_RS22265 (4370771) 4370771..4371292 + 522 WP_001055874.1 flavodoxin FldB -
FNA55_RS22270 (4371332) 4371332..4371739 - 408 WP_000244777.1 protein YgfX Toxin
FNA55_RS22275 (4371720) 4371720..4371986 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FNA55_RS22280 (4372229) 4372229..4373209 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
FNA55_RS22285 (4373405) 4373405..4374064 - 660 WP_000250274.1 hemolysin III family protein -
FNA55_RS22290 (4374228) 4374228..4374539 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
FNA55_RS22295 (4374584) 4374584..4376017 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
FNA55_RS22300 (4376074) 4376074..4376817 - 744 WP_000951938.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T128705 WP_000244777.1 NZ_CP041511:c4371739-4371332 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T128705 NZ_CP041511:c4371739-4371332 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCAGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT128705 WP_000354046.1 NZ_CP041511:c4371986-4371720 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT128705 NZ_CP041511:c4371986-4371720 [Shigella sonnei]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References