128701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2817340..2817824 Replicon chromosome
Accession NZ_CP041511
Organism Shigella sonnei strain KCCM 41282

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag FNA55_RS14190 Protein ID WP_014334020.1
Coordinates 2817340..2817630 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag FNA55_RS14195 Protein ID WP_005142544.1
Coordinates 2817630..2817824 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA55_RS14145 (2813136) 2813136..2813327 - 192 WP_001090204.1 DUF1482 family protein -
FNA55_RS14150 (2813324) 2813324..2813512 - 189 WP_000449206.1 cell division inhibition protein DicB -
FNA55_RS14155 (2813523) 2813523..2813618 - 96 Protein_2720 transcriptional regulator -
FNA55_RS14160 (2813675) 2813675..2814372 + 698 WP_237158186.1 IS1-like element IS1A family transposase -
FNA55_RS14165 (2814366) 2814366..2815154 - 789 WP_000935603.1 Rha family phage regulatory protein -
FNA55_RS14175 (2815687) 2815687..2816384 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
FNA55_RS14180 (2816532) 2816532..2816897 - 366 WP_024174355.1 hypothetical protein -
FNA55_RS14185 (2816909) 2816909..2817061 - 153 WP_000379558.1 DUF1391 family protein -
FNA55_RS14190 (2817340) 2817340..2817630 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNA55_RS14195 (2817630) 2817630..2817824 - 195 WP_005142544.1 hypothetical protein Antitoxin
FNA55_RS14200 (2817844) 2817844..2818329 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
FNA55_RS14205 (2818456) 2818456..2818719 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
FNA55_RS14210 (2818716) 2818716..2819141 + 426 WP_000693826.1 toxin YdaT family protein -
FNA55_RS14215 (2819213) 2819213..2820277 + 1065 WP_001262380.1 hypothetical protein -
FNA55_RS14220 (2820284) 2820284..2821030 + 747 WP_000788740.1 ATP-binding protein -
FNA55_RS14225 (2821052) 2821052..2821417 + 366 Protein_2733 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / sodCI / rhs/PAAR / rhs/PAAR / vgrG/tssI 2718125..2951035 232910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T128701 WP_014334020.1 NZ_CP041511:c2817630-2817340 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T128701 NZ_CP041511:c2817630-2817340 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT128701 WP_005142544.1 NZ_CP041511:c2817824-2817630 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT128701 NZ_CP041511:c2817824-2817630 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References