Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1558389..1559007 Replicon chromosome
Accession NZ_CP041511
Organism Shigella sonnei strain KCCM 41282

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FNA55_RS07570 Protein ID WP_001291435.1
Coordinates 1558389..1558607 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FNA55_RS07575 Protein ID WP_000344800.1
Coordinates 1558633..1559007 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA55_RS07545 (1553639) 1553639..1553992 + 354 WP_000878140.1 DUF1428 domain-containing protein -
FNA55_RS07550 (1554034) 1554034..1555582 - 1549 Protein_1455 cyclic-guanylate-specific phosphodiesterase PdeB -
FNA55_RS07560 (1557081) 1557081..1557551 - 471 WP_000136192.1 YlaC family protein -
FNA55_RS07565 (1557667) 1557667..1558218 - 552 WP_000102564.1 maltose O-acetyltransferase -
FNA55_RS07570 (1558389) 1558389..1558607 - 219 WP_001291435.1 HHA domain-containing protein Toxin
FNA55_RS07575 (1558633) 1558633..1559007 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FNA55_RS07580 (1559553) 1559553..1562702 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
FNA55_RS07585 (1562725) 1562725..1563918 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T128692 WP_001291435.1 NZ_CP041511:c1558607-1558389 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T128692 NZ_CP041511:c1558607-1558389 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT128692 WP_000344800.1 NZ_CP041511:c1559007-1558633 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT128692 NZ_CP041511:c1559007-1558633 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References