Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 55107..55629 Replicon plasmid pYPE3-92k-tetX4
Accession NZ_CP041453
Organism Escherichia coli strain YPE3

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag FNP78_RS23635 Protein ID WP_000220560.1
Coordinates 55348..55629 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FNP78_RS23630 Protein ID WP_000121743.1
Coordinates 55107..55358 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNP78_RS23595 50778..51059 + 282 WP_001185482.1 hypothetical protein -
FNP78_RS23600 51084..52061 + 978 WP_024245156.1 hypothetical protein -
FNP78_RS23605 52058..52483 - 426 WP_000202942.1 hypothetical protein -
FNP78_RS23610 52551..52997 - 447 Protein_65 hypothetical protein -
FNP78_RS23615 53037..53873 - 837 WP_001050931.1 replication initiation protein -
FNP78_RS23630 55107..55358 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FNP78_RS23635 55348..55629 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNP78_RS23640 55704..56401 + 698 Protein_69 IS1 family transposase -
FNP78_RS23650 56547..56804 + 258 WP_105278499.1 hypothetical protein -
FNP78_RS23655 56841..57809 - 969 WP_077783444.1 IS5 family transposase -
FNP78_RS23665 57844..58119 + 276 Protein_72 peptidoglycan DD-metalloendopeptidase family protein -
FNP78_RS23670 58153..58350 - 198 WP_000843497.1 DUF2933 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mef(B) / sul3 / dfrA5 / tet(X4) / floR - 1..92973 92973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T128688 WP_000220560.1 NZ_CP041453:55348-55629 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T128688 NZ_CP041453:55348-55629 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT128688 WP_000121743.1 NZ_CP041453:55107-55358 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT128688 NZ_CP041453:55107-55358 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References