Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2931964..2932795 | Replicon | chromosome |
| Accession | NZ_CP041448 | ||
| Organism | Escherichia coli strain YPE10 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | FNP79_RS14910 | Protein ID | WP_130065512.1 |
| Coordinates | 2932421..2932795 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B3Y195 |
| Locus tag | FNP79_RS14905 | Protein ID | WP_001285585.1 |
| Coordinates | 2931964..2932332 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNP79_RS14860 | 2927626..2928309 | + | 684 | WP_000775500.1 | hypothetical protein | - |
| FNP79_RS14865 | 2928325..2928735 | + | 411 | WP_000846713.1 | hypothetical protein | - |
| FNP79_RS14875 | 2928956..2929045 | + | 90 | Protein_2767 | DUF945 domain-containing protein | - |
| FNP79_RS14880 | 2929100..2929797 | + | 698 | Protein_2768 | IS1 family transposase | - |
| FNP79_RS14885 | 2929813..2930553 | + | 741 | Protein_2769 | DUF945 domain-containing protein | - |
| FNP79_RS14890 | 2930635..2931114 | + | 480 | WP_000860076.1 | antirestriction protein | - |
| FNP79_RS14895 | 2931130..2931606 | + | 477 | WP_001186773.1 | RadC family protein | - |
| FNP79_RS14900 | 2931669..2931890 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| FNP79_RS14905 | 2931964..2932332 | + | 369 | WP_001285585.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| FNP79_RS14910 | 2932421..2932795 | + | 375 | WP_130065512.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| FNP79_RS14915 | 2932792..2932986 | + | 195 | WP_000988600.1 | hypothetical protein | - |
| FNP79_RS14920 | 2932999..2933112 | + | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| FNP79_RS14925 | 2933401..2933529 | - | 129 | Protein_2777 | transposase domain-containing protein | - |
| FNP79_RS14930 | 2933601..2933783 | + | 183 | WP_001016348.1 | hypothetical protein | - |
| FNP79_RS14935 | 2933884..2934213 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| FNP79_RS14940 | 2934385..2935443 | - | 1059 | WP_064670363.1 | FUSC family protein | - |
| FNP79_RS14945 | 2935641..2936114 | - | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| FNP79_RS14950 | 2936233..2937399 | - | 1167 | WP_016247321.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2923301..2978465 | 55164 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13897.96 Da Isoelectric Point: 8.4952
>T128662 WP_130065512.1 NZ_CP041448:2932421-2932795 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFANERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFANERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T128662 NZ_CP041448:2932421-2932795 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCAATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCAATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.48 Da Isoelectric Point: 6.3139
>AT128662 WP_001285585.1 NZ_CP041448:2931964-2932332 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT128662 NZ_CP041448:2931964-2932332 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|