Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1875209..1876007 Replicon chromosome
Accession NZ_CP041448
Organism Escherichia coli strain YPE10

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag FNP79_RS09445 Protein ID WP_000854898.1
Coordinates 1875630..1876007 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4GA79
Locus tag FNP79_RS09440 Protein ID WP_001390639.1
Coordinates 1875209..1875583 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNP79_RS09400 1870401..1871471 + 1071 WP_059239982.1 patatin-like phospholipase family protein -
FNP79_RS09405 1871607..1872284 + 678 WP_059239983.1 hypothetical protein -
FNP79_RS09410 1872300..1872710 + 411 WP_000846713.1 hypothetical protein -
FNP79_RS09420 1872931..1873752 + 822 WP_072652286.1 DUF945 domain-containing protein -
FNP79_RS09425 1873844..1874329 + 486 WP_032180519.1 antirestriction protein -
FNP79_RS09430 1874345..1874821 + 477 WP_001186768.1 RadC family protein -
FNP79_RS09435 1874908..1875129 + 222 WP_000692352.1 DUF987 domain-containing protein -
FNP79_RS09440 1875209..1875583 + 375 WP_001390639.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FNP79_RS09445 1875630..1876007 + 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
FNP79_RS09450 1876004..1876492 + 489 WP_072650510.1 hypothetical protein -
FNP79_RS09455 1876504..1876701 + 198 WP_000839285.1 DUF957 domain-containing protein -
FNP79_RS09460 1876798..1877640 + 843 WP_072650511.1 DUF4942 domain-containing protein -
FNP79_RS09470 1878111..1879049 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
FNP79_RS09475 1879104..1879841 + 738 WP_000283667.1 zinc-binding phosphatase -
FNP79_RS09480 1879865..1880419 + 555 WP_001001921.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T128650 WP_000854898.1 NZ_CP041448:1875630-1876007 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T128650 NZ_CP041448:1875630-1876007 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13566.36 Da        Isoelectric Point: 6.0568

>AT128650 WP_001390639.1 NZ_CP041448:1875209-1875583 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT128650 NZ_CP041448:1875209-1875583 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4GA79

References