Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1891977..1892808 Replicon chromosome
Accession NZ_CP041442
Organism Escherichia coli strain YPE12

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FNP80_RS10790 Protein ID WP_000854814.1
Coordinates 1891977..1892351 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FNP80_RS10795 Protein ID WP_001285585.1
Coordinates 1892440..1892808 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNP80_RS10750 1887373..1888539 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FNP80_RS10755 1888658..1889131 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
FNP80_RS10760 1889329..1890387 + 1059 WP_064670363.1 FUSC family protein -
FNP80_RS10765 1890559..1890888 + 330 WP_000450409.1 DUF496 family protein -
FNP80_RS10770 1890989..1891171 - 183 WP_001016348.1 hypothetical protein -
FNP80_RS10775 1891243..1891371 + 129 Protein_1776 transposase domain-containing protein -
FNP80_RS10780 1891660..1891773 - 114 WP_001161660.1 DUF957 domain-containing protein -
FNP80_RS10785 1891786..1891980 - 195 WP_000988600.1 hypothetical protein -
FNP80_RS10790 1891977..1892351 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FNP80_RS10795 1892440..1892808 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FNP80_RS10800 1892882..1893103 - 222 WP_000692323.1 DUF987 domain-containing protein -
FNP80_RS10805 1893166..1893642 - 477 WP_001186773.1 RadC family protein -
FNP80_RS10810 1893658..1894137 - 480 WP_000860076.1 antirestriction protein -
FNP80_RS10815 1894219..1895040 - 822 WP_064670364.1 DUF945 domain-containing protein -
FNP80_RS10825 1895261..1895671 - 411 WP_000846713.1 hypothetical protein -
FNP80_RS10830 1895687..1896370 - 684 WP_000775500.1 hypothetical protein -
FNP80_RS10835 1896506..1897576 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1844435..1904164 59729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T128627 WP_000854814.1 NZ_CP041442:c1892351-1891977 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T128627 NZ_CP041442:c1892351-1891977 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT128627 WP_001285585.1 NZ_CP041442:c1892808-1892440 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT128627 NZ_CP041442:c1892808-1892440 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References