Detailed information of TA system TA128586

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 784985..785820
• Replicon: chromosome
• Accession: NZ_CP041437
• Organism: Escherichia coli strain STEC005

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FNE80_RS03795
• Protein ID: WP_097741816.1
• Coordinates: 784985..785362 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FNE80_RS03800
• Protein ID: WP_061330307.1
• Coordinates: 785452..785820 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE80_RS03770	780884..781420	+	537	WP_000942795.1	GspM family type II secretion system protein YghD	-
FNE80_RS03775	781755..783290	-	1536	WP_097741818.1	EAL domain-containing protein	-
FNE80_RS03780	783361..784206	-	846	WP_097741817.1	DUF4942 domain-containing protein	-
FNE80_RS03785	784291..784488	-	198	WP_001546507.1	DUF957 domain-containing protein	-
FNE80_RS03790	784500..784988	-	489	WP_000761672.1	hypothetical protein	-
FNE80_RS03795	784985..785362	-	378	WP_097741816.1	TA system toxin CbtA family protein	Toxin
FNE80_RS03800	785452..785820	-	369	WP_061330307.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FNE80_RS03805	785836..786480	-	645	WP_097296686.1	antitoxin of toxin-antitoxin stability system	-
FNE80_RS03810	786499..786720	-	222	WP_000692300.1	DUF987 domain-containing protein	-
FNE80_RS03815	786789..787265	-	477	WP_001186774.1	RadC family protein	-
FNE80_RS03820	787281..787754	-	474	WP_097741815.1	antirestriction protein	-
FNE80_RS03825	787848..788093	-	246	WP_097741814.1	antirestriction protein	-
FNE80_RS03830	788093..788911	-	819	WP_097741813.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14058.96 Da
• Isoelectric Point: 6.9571

>T128586 WP_097741816.1 NZ_CP041437:c785362-784985 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMARDNYRTVNDITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T128586 NZ_CP041437:c785362-784985 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTATGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13782.61 Da
• Isoelectric Point: 5.8808

>AT128586 WP_061330307.1 NZ_CP041437:c785820-785452 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT128586 NZ_CP041437:c785820-785452 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA