Detailed information of TA system TA128580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4516600..4517644
• Replicon: chromosome
• Accession: NZ_CP041435
• Organism: Escherichia coli strain STEC309

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FNE81_RS22075
• Protein ID: WP_053878051.1
• Coordinates: 4516600..4517148 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A799QL68
• Locus tag: FNE81_RS22080
• Protein ID: WP_059242328.1
• Coordinates: 4517171..4517644 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE81_RS22025	4511831..4512655	+	825	WP_161619113.1	YfdQ family protein	-
FNE81_RS22030	4512784..4513320	+	537	WP_000008178.1	5'-deoxynucleotidase	-
FNE81_RS22035	4513311..4513673	+	363	WP_097455379.1	hypothetical protein	-
FNE81_RS22040	4513670..4513873	+	204	WP_000111289.1	hypothetical protein	-
FNE81_RS22045	4513866..4514105	+	240	WP_000476211.1	hypothetical protein	-
FNE81_RS22050	4514102..4514356	+	255	WP_027661982.1	hypothetical protein	-
FNE81_RS22055	4514349..4514657	+	309	Protein_4320	hypothetical protein	-
FNE81_RS22060	4514723..4515685	+	963	WP_161619114.1	ead/Ea22-like family protein	-
FNE81_RS22065	4515685..4516257	+	573	WP_097455382.1	3'-5' exoribonuclease	-
FNE81_RS22070	4516294..4516566	+	273	WP_001093911.1	pyocin activator PrtN family protein	-
FNE81_RS22075	4516600..4517148	-	549	WP_053878051.1	hypothetical protein	Toxin
FNE81_RS22080	4517171..4517644	-	474	WP_059242328.1	SocA family protein	Antitoxin
FNE81_RS22085	4517932..4518054	-	123	WP_001300034.1	hypothetical protein	-
FNE81_RS22090	4518418..4519408	-	991	Protein_4327	DUF2713 family protein	-
FNE81_RS22100	4519726..4520241	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
FNE81_RS22105	4520283..4520492	-	210	WP_001030593.1	CsbD family protein	-
FNE81_RS22110	4520608..4521933	-	1326	WP_001298861.1	MATE family efflux transporter DinF	-
FNE81_RS22115	4522006..4522614	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	4464880..4522614	57734

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20096.62 Da
• Isoelectric Point: 4.5890

>T128580 WP_053878051.1 NZ_CP041435:c4517148-4516600 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T128580 NZ_CP041435:c4517148-4516600 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17369.87 Da
• Isoelectric Point: 7.9143

>AT128580 WP_059242328.1 NZ_CP041435:c4517644-4517171 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT128580 NZ_CP041435:c4517644-4517171 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A799QL68