Detailed information of TA system TA128549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4703382..4704426
• Replicon: chromosome
• Accession: NZ_CP041433
• Organism: Escherichia coli strain STEC313

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FNE82_RS23035
• Protein ID: WP_053878051.1
• Coordinates: 4703382..4703930 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A799QL68
• Locus tag: FNE82_RS23040
• Protein ID: WP_059242328.1
• Coordinates: 4703953..4704426 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE82_RS22985	4698613..4699437	+	825	WP_161620816.1	YfdQ family protein	-
FNE82_RS22990	4699566..4700102	+	537	WP_000008178.1	5'-deoxynucleotidase	-
FNE82_RS22995	4700093..4700455	+	363	WP_097455379.1	hypothetical protein	-
FNE82_RS23000	4700452..4700655	+	204	WP_000111289.1	hypothetical protein	-
FNE82_RS23005	4700648..4700887	+	240	WP_000476211.1	hypothetical protein	-
FNE82_RS23010	4700884..4701138	+	255	WP_027661982.1	hypothetical protein	-
FNE82_RS23015	4701131..4701439	+	309	Protein_4507	hypothetical protein	-
FNE82_RS23020	4701505..4702467	+	963	WP_136769110.1	ead/Ea22-like family protein	-
FNE82_RS23025	4702467..4703039	+	573	WP_097455382.1	3'-5' exoribonuclease	-
FNE82_RS23030	4703076..4703348	+	273	WP_001093911.1	pyocin activator PrtN family protein	-
FNE82_RS23035	4703382..4703930	-	549	WP_053878051.1	hypothetical protein	Toxin
FNE82_RS23040	4703953..4704426	-	474	WP_059242328.1	SocA family protein	Antitoxin
FNE82_RS23045	4704714..4704836	-	123	WP_001300034.1	hypothetical protein	-
FNE82_RS23050	4705200..4706191	-	992	Protein_4514	DUF2713 family protein	-
FNE82_RS23060	4706509..4707024	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
FNE82_RS23065	4707066..4707275	-	210	WP_001030593.1	CsbD family protein	-
FNE82_RS23070	4707391..4708716	-	1326	WP_001352579.1	MATE family efflux transporter DinF	-
FNE82_RS23075	4708789..4709397	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	4635267..4709875	74608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20096.62 Da
• Isoelectric Point: 4.5890

>T128549 WP_053878051.1 NZ_CP041433:c4703930-4703382 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T128549 NZ_CP041433:c4703930-4703382 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17369.87 Da
• Isoelectric Point: 7.9143

>AT128549 WP_059242328.1 NZ_CP041433:c4704426-4703953 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT128549 NZ_CP041433:c4704426-4703953 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A799QL68