Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2200132..2200930 | Replicon | chromosome |
| Accession | NZ_CP041433 | ||
| Organism | Escherichia coli strain STEC313 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | FNE82_RS10700 | Protein ID | WP_061356740.1 |
| Coordinates | 2200132..2200509 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M1EW42 |
| Locus tag | FNE82_RS10705 | Protein ID | WP_032153712.1 |
| Coordinates | 2200556..2200930 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE82_RS10670 | 2195416..2196954 | - | 1539 | WP_001187183.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| FNE82_RS10675 | 2197829..2198155 | - | 327 | WP_021537629.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FNE82_RS10680 | 2198152..2198415 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FNE82_RS10685 | 2198487..2199353 | - | 867 | WP_032153714.1 | DUF4942 domain-containing protein | - |
| FNE82_RS10690 | 2199438..2199635 | - | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| FNE82_RS10695 | 2199647..2200135 | - | 489 | WP_061356741.1 | hypothetical protein | - |
| FNE82_RS10700 | 2200132..2200509 | - | 378 | WP_061356740.1 | TA system toxin CbtA family protein | Toxin |
| FNE82_RS10705 | 2200556..2200930 | - | 375 | WP_032153712.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| FNE82_RS10710 | 2201010..2201231 | - | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| FNE82_RS10715 | 2201300..2201776 | - | 477 | WP_061356739.1 | RadC family protein | - |
| FNE82_RS10720 | 2201792..2202277 | - | 486 | WP_061356738.1 | antirestriction protein | - |
| FNE82_RS10725 | 2202369..2203187 | - | 819 | WP_001234621.1 | DUF945 domain-containing protein | - |
| FNE82_RS10730 | 2203286..2203519 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| FNE82_RS10735 | 2203525..2204202 | - | 678 | WP_001097305.1 | hypothetical protein | - |
| FNE82_RS10740 | 2204350..2205030 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | iroB | 2187603..2230778 | 43175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14149.13 Da Isoelectric Point: 7.8045
>T128527 WP_061356740.1 NZ_CP041433:c2200509-2200132 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYDLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYDLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T128527 NZ_CP041433:c2200509-2200132 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGACCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGACCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13697.51 Da Isoelectric Point: 6.6240
>AT128527 WP_032153712.1 NZ_CP041433:c2200930-2200556 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT128527 NZ_CP041433:c2200930-2200556 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|