Detailed information of TA system TA128520

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 802072..802907
• Replicon: chromosome
• Accession: NZ_CP041433
• Organism: Escherichia coli strain STEC313

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FNE82_RS03840
• Protein ID: WP_160520337.1
• Coordinates: 802072..802449 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FNE82_RS03845
• Protein ID: WP_061356704.1
• Coordinates: 802539..802907 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE82_RS03815	797971..798507	+	537	WP_000942798.1	GspM family type II secretion system protein YghD	-
FNE82_RS03820	798842..800377	-	1536	WP_097741818.1	EAL domain-containing protein	-
FNE82_RS03825	800448..801293	-	846	WP_097741817.1	DUF4942 domain-containing protein	-
FNE82_RS03830	801378..801575	-	198	WP_001546507.1	DUF957 domain-containing protein	-
FNE82_RS03835	801587..802075	-	489	WP_000761672.1	hypothetical protein	-
FNE82_RS03840	802072..802449	-	378	WP_160520337.1	TA system toxin CbtA family protein	Toxin
FNE82_RS03845	802539..802907	-	369	WP_061356704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FNE82_RS03850	802957..803601	-	645	WP_160520336.1	antitoxin of toxin-antitoxin stability system	-
FNE82_RS03855	803620..803841	-	222	WP_000692353.1	DUF987 domain-containing protein	-
FNE82_RS03860	803910..804386	-	477	WP_001186770.1	RadC family protein	-
FNE82_RS03865	804402..804875	-	474	WP_160520335.1	antirestriction protein	-
FNE82_RS03870	804969..805214	-	246	WP_089578131.1	antirestriction protein	-
FNE82_RS03875	805214..806032	-	819	WP_097741813.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14030.91 Da
• Isoelectric Point: 6.6303

>T128520 WP_160520337.1 NZ_CP041433:c802449-802072 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMARDNYRTVNDITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T128520 NZ_CP041433:c802449-802072 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13761.51 Da
• Isoelectric Point: 5.9618

>AT128520 WP_061356704.1 NZ_CP041433:c802907-802539 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT128520 NZ_CP041433:c802907-802539 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA