Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 62445..63004 Replicon plasmid pSTEC316
Accession NZ_CP041432
Organism Escherichia coli strain STEC316

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FNE83_RS26275 Protein ID WP_032084131.1
Coordinates 62445..62720 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FNE83_RS26280 Protein ID WP_032084130.1
Coordinates 62720..63004 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE83_RS26245 57713..57916 - 204 Protein_70 transposase -
FNE83_RS26250 58680..59377 - 698 Protein_71 IS1 family transposase -
FNE83_RS26255 59783..60706 + 924 WP_032084040.1 hypothetical protein -
FNE83_RS26260 60990..61424 + 435 Protein_73 hypothetical protein -
FNE83_RS26265 61442..61788 - 347 Protein_74 hypothetical protein -
FNE83_RS26270 62058..62339 - 282 WP_001105066.1 hypothetical protein -
FNE83_RS26275 62445..62720 - 276 WP_032084131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNE83_RS26280 62720..63004 - 285 WP_032084130.1 ribbon-helix-helix domain-containing protein Antitoxin
FNE83_RS26285 63082..63168 + 87 Protein_78 ATP-binding protein -
FNE83_RS26290 63240..63365 + 126 Protein_79 IS256 family transposase -
FNE83_RS26295 63421..64263 - 843 WP_160391234.1 hypothetical protein -
FNE83_RS26300 64414..64794 - 381 WP_143361631.1 hypothetical protein -
FNE83_RS26305 64910..65602 - 693 WP_181573844.1 fimbrial chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..80029 80029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T128517 WP_032084131.1 NZ_CP041432:c62720-62445 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFSGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T128517 NZ_CP041432:c62720-62445 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTTCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.92 Da        Isoelectric Point: 5.6558

>AT128517 WP_032084130.1 NZ_CP041432:c63004-62720 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQTW
ADSLNTDNPLPVPR

Download         Length: 285 bp

>AT128517 NZ_CP041432:c63004-62720 [Escherichia coli]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGATCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGACCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References