Detailed information of TA system TA128510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4850287..4851331
• Replicon: chromosome
• Accession: NZ_CP041431
• Organism: Escherichia coli strain STEC316

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FNE83_RS24080
• Protein ID: WP_053878051.1
• Coordinates: 4850287..4850835 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A799QL68
• Locus tag: FNE83_RS24085
• Protein ID: WP_059242328.1
• Coordinates: 4850858..4851331 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE83_RS24025	4845518..4846342	+	825	WP_161620816.1	YfdQ family protein	-
FNE83_RS24030	4846471..4847007	+	537	WP_000008178.1	5'-deoxynucleotidase	-
FNE83_RS24035	4846998..4847360	+	363	WP_097455379.1	hypothetical protein	-
FNE83_RS24040	4847357..4847560	+	204	WP_000111289.1	hypothetical protein	-
FNE83_RS24045	4847553..4847792	+	240	WP_000476211.1	hypothetical protein	-
FNE83_RS24050	4847789..4848043	+	255	WP_027661982.1	hypothetical protein	-
FNE83_RS24055	4848036..4848344	+	309	Protein_4714	hypothetical protein	-
FNE83_RS24060	4848410..4849105	+	696	WP_161620817.1	ead/Ea22-like family protein	-
FNE83_RS24065	4849160..4849372	+	213	Protein_4716	DUF551 domain-containing protein	-
FNE83_RS24070	4849372..4849944	+	573	WP_097455382.1	3'-5' exoribonuclease	-
FNE83_RS24075	4849981..4850253	+	273	WP_001093911.1	pyocin activator PrtN family protein	-
FNE83_RS24080	4850287..4850835	-	549	WP_053878051.1	hypothetical protein	Toxin
FNE83_RS24085	4850858..4851331	-	474	WP_059242328.1	SocA family protein	Antitoxin
FNE83_RS24090	4851619..4851741	-	123	WP_001300034.1	hypothetical protein	-
FNE83_RS24095	4852105..4853096	-	992	Protein_4722	DUF2713 family protein	-
FNE83_RS24105	4853414..4853929	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
FNE83_RS24110	4853971..4854180	-	210	WP_001030593.1	CsbD family protein	-
FNE83_RS24115	4854296..4855621	-	1326	WP_001352579.1	MATE family efflux transporter DinF	-
FNE83_RS24120	4855694..4856302	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	4799093..4856302	57209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20096.62 Da
• Isoelectric Point: 4.5890

>T128510 WP_053878051.1 NZ_CP041431:c4850835-4850287 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T128510 NZ_CP041431:c4850835-4850287 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17369.87 Da
• Isoelectric Point: 7.9143

>AT128510 WP_059242328.1 NZ_CP041431:c4851331-4850858 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT128510 NZ_CP041431:c4851331-4850858 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A799QL68