Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4706593..4707428 | Replicon | chromosome |
| Accession | NZ_CP041431 | ||
| Organism | Escherichia coli strain STEC316 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W3AJH4 |
| Locus tag | FNE83_RS23285 | Protein ID | WP_000854721.1 |
| Coordinates | 4707051..4707428 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | FNE83_RS23280 | Protein ID | WP_161620405.1 |
| Coordinates | 4706593..4706961 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE83_RS23240 | 4702369..4703049 | + | 681 | WP_089581517.1 | WYL domain-containing protein | - |
| FNE83_RS23245 | 4703311..4703589 | + | 279 | WP_001545361.1 | hypothetical protein | - |
| FNE83_RS23250 | 4703618..4703908 | + | 291 | WP_001608659.1 | hypothetical protein | - |
| FNE83_RS23255 | 4703928..4704239 | + | 312 | WP_001608658.1 | hypothetical protein | - |
| FNE83_RS23260 | 4704337..4705155 | + | 819 | WP_097331407.1 | DUF945 domain-containing protein | - |
| FNE83_RS23265 | 4705247..4705732 | + | 486 | WP_000206660.1 | antirestriction protein | - |
| FNE83_RS23270 | 4705748..4706224 | + | 477 | WP_001186742.1 | RadC family protein | - |
| FNE83_RS23275 | 4706293..4706514 | + | 222 | WP_000692295.1 | DUF987 domain-containing protein | - |
| FNE83_RS23280 | 4706593..4706961 | + | 369 | WP_161620405.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FNE83_RS23285 | 4707051..4707428 | + | 378 | WP_000854721.1 | TA system toxin CbtA family protein | Toxin |
| FNE83_RS23290 | 4707425..4707913 | + | 489 | WP_000761678.1 | hypothetical protein | - |
| FNE83_RS23295 | 4707925..4708122 | + | 198 | WP_000839239.1 | DUF957 domain-containing protein | - |
| FNE83_RS23300 | 4708207..4709073 | + | 867 | WP_161620404.1 | DUF4942 domain-containing protein | - |
| FNE83_RS23305 | 4709145..4709408 | + | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FNE83_RS23310 | 4709405..4709731 | + | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FNE83_RS23315 | 4710614..4712152 | + | 1539 | WP_001187183.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.12 Da Isoelectric Point: 8.2904
>T128508 WP_000854721.1 NZ_CP041431:4707051-4707428 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T128508 NZ_CP041431:4707051-4707428 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13609.40 Da Isoelectric Point: 6.6252
>AT128508 WP_161620405.1 NZ_CP041431:4706593-4706961 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT128508 NZ_CP041431:4706593-4706961 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|