Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4427631..4428466 Replicon chromosome
Accession NZ_CP041431
Organism Escherichia coli strain STEC316

Toxin (Protein)


Gene name yeeV Uniprot ID V0Z9U3
Locus tag FNE83_RS21910 Protein ID WP_000854750.1
Coordinates 4427631..4428008 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J7L0S7
Locus tag FNE83_RS21915 Protein ID WP_001278231.1
Coordinates 4428098..4428466 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE83_RS21890 4423163..4426054 - 2892 WP_001395333.1 DEAD/DEAH box helicase family protein -
FNE83_RS26555 4426706..4426852 - 147 WP_001290178.1 hypothetical protein -
FNE83_RS21900 4426937..4427134 - 198 WP_000839280.1 DUF957 domain-containing protein -
FNE83_RS21905 4427146..4427634 - 489 WP_000761685.1 hypothetical protein -
FNE83_RS21910 4427631..4428008 - 378 WP_000854750.1 TA system toxin CbtA family protein Toxin
FNE83_RS21915 4428098..4428466 - 369 WP_001278231.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FNE83_RS21920 4428629..4428850 - 222 WP_000691819.1 DUF987 domain-containing protein -
FNE83_RS21925 4428937..4429413 - 477 WP_001367707.1 RadC family protein -
FNE83_RS21930 4429429..4429914 - 486 WP_000206658.1 antirestriction protein -
FNE83_RS21935 4430006..4430824 - 819 WP_001234615.1 DUF945 domain-containing protein -
FNE83_RS21940 4430923..4431156 - 234 WP_001278287.1 DUF905 family protein -
FNE83_RS21945 4431162..4431839 - 678 WP_001097305.1 hypothetical protein -
FNE83_RS21950 4431987..4432667 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13919.90 Da        Isoelectric Point: 8.2905

>T128506 WP_000854750.1 NZ_CP041431:c4428008-4427631 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T128506 NZ_CP041431:c4428008-4427631 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT128506 WP_001278231.1 NZ_CP041431:c4428466-4428098 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLEIMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT128506 NZ_CP041431:c4428466-4428098 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAATCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0Z9U3

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7L0S7

References