Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 841150..841948 Replicon chromosome
Accession NZ_CP041431
Organism Escherichia coli strain STEC316

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FNE83_RS04125 Protein ID WP_072713924.1
Coordinates 841150..841527 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FNE83_RS04130 Protein ID WP_072713922.1
Coordinates 841574..841948 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE83_RS04095 837043..837579 + 537 WP_000942798.1 GspM family type II secretion system protein YghD -
FNE83_RS04100 837914..839448 - 1535 Protein_807 EAL domain-containing protein -
FNE83_RS26415 839519..840367 - 849 Protein_808 DUF4942 domain-containing protein -
FNE83_RS04115 840456..840653 - 198 WP_000839243.1 DUF957 domain-containing protein -
FNE83_RS04120 840665..841153 - 489 WP_072713926.1 hypothetical protein -
FNE83_RS04125 841150..841527 - 378 WP_072713924.1 TA system toxin CbtA family protein Toxin
FNE83_RS04130 841574..841948 - 375 WP_072713922.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FNE83_RS04135 841998..842642 - 645 WP_096858933.1 antitoxin of toxin-antitoxin stability system -
FNE83_RS04140 842661..842882 - 222 WP_000692326.1 DUF987 domain-containing protein -
FNE83_RS04145 842945..843421 - 477 WP_122996610.1 RadC family protein -
FNE83_RS04150 843437..843922 - 486 WP_000206671.1 antirestriction protein -
FNE83_RS04155 844014..844832 - 819 WP_021536653.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14261.29 Da        Isoelectric Point: 7.2922

>T128481 WP_072713924.1 NZ_CP041431:c841527-841150 [Escherichia coli]
MKTLPDTHVREASRCLSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLITRDNYRKVNDITLGKHPEAKQ

Download         Length: 378 bp

>T128481 NZ_CP041431:c841527-841150 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCTGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATAACCCGCGA
CAACTACAGAAAGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14039.87 Da        Isoelectric Point: 6.4772

>AT128481 WP_072713922.1 NZ_CP041431:c841948-841574 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARELTCEADSLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT128481 NZ_CP041431:c841948-841574 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGAGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References