Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 22828..23387 Replicon plasmid pSTEC367
Accession NZ_CP041430
Organism Escherichia coli strain STEC367

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FNE84_RS24935 Protein ID WP_032084131.1
Coordinates 22828..23103 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FNE84_RS24940 Protein ID WP_032084130.1
Coordinates 23103..23387 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE84_RS24905 18096..18299 - 204 Protein_26 transposase -
FNE84_RS24910 19063..19760 - 698 Protein_27 IS1 family transposase -
FNE84_RS24915 20166..21089 + 924 WP_032084040.1 hypothetical protein -
FNE84_RS24920 21373..21807 + 435 Protein_29 hypothetical protein -
FNE84_RS24925 21825..22171 - 347 Protein_30 hypothetical protein -
FNE84_RS24930 22441..22722 - 282 WP_001105066.1 hypothetical protein -
FNE84_RS24935 22828..23103 - 276 WP_032084131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNE84_RS24940 23103..23387 - 285 WP_032084130.1 ribbon-helix-helix domain-containing protein Antitoxin
FNE84_RS24945 23465..23551 + 87 Protein_34 ATP-binding protein -
FNE84_RS24950 23623..23748 + 126 Protein_35 IS256 family transposase -
FNE84_RS24955 23804..24646 - 843 WP_160391234.1 hypothetical protein -
FNE84_RS24960 24797..25177 - 381 WP_143361631.1 hypothetical protein -
FNE84_RS24965 25293..25985 - 693 WP_181573844.1 fimbrial chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..80039 80039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T128473 WP_032084131.1 NZ_CP041430:c23103-22828 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFSGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T128473 NZ_CP041430:c23103-22828 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTTCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.92 Da        Isoelectric Point: 5.6558

>AT128473 WP_032084130.1 NZ_CP041430:c23387-23103 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQTW
ADSLNTDNPLPVPR

Download         Length: 285 bp

>AT128473 NZ_CP041430:c23387-23103 [Escherichia coli]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGATCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGACCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References