Detailed information of TA system TA128471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4693864..4694908
• Replicon: chromosome
• Accession: NZ_CP041429
• Organism: Escherichia coli strain STEC367

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FNE84_RS22965
• Protein ID: WP_053878051.1
• Coordinates: 4693864..4694412 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A799QL68
• Locus tag: FNE84_RS22970
• Protein ID: WP_059242328.1
• Coordinates: 4694435..4694908 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE84_RS22915	4689095..4689919	+	825	WP_161620816.1	YfdQ family protein	-
FNE84_RS22920	4690048..4690584	+	537	WP_000008178.1	5'-deoxynucleotidase	-
FNE84_RS22925	4690575..4690937	+	363	WP_097455379.1	hypothetical protein	-
FNE84_RS22930	4690934..4691137	+	204	WP_000111289.1	hypothetical protein	-
FNE84_RS22935	4691130..4691369	+	240	WP_000476211.1	hypothetical protein	-
FNE84_RS22940	4691366..4691620	+	255	WP_027661982.1	hypothetical protein	-
FNE84_RS22945	4691613..4691921	+	309	Protein_4490	hypothetical protein	-
FNE84_RS22950	4691987..4692949	+	963	WP_136769110.1	ead/Ea22-like family protein	-
FNE84_RS22955	4692949..4693521	+	573	WP_097455382.1	3'-5' exoribonuclease	-
FNE84_RS22960	4693558..4693830	+	273	WP_001093911.1	pyocin activator PrtN family protein	-
FNE84_RS22965	4693864..4694412	-	549	WP_053878051.1	hypothetical protein	Toxin
FNE84_RS22970	4694435..4694908	-	474	WP_059242328.1	SocA family protein	Antitoxin
FNE84_RS22975	4695196..4695318	-	123	WP_001300034.1	hypothetical protein	-
FNE84_RS22980	4695682..4696673	-	992	Protein_4497	DUF2713 family protein	-
FNE84_RS22990	4696991..4697506	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
FNE84_RS22995	4697548..4697757	-	210	WP_001030593.1	CsbD family protein	-
FNE84_RS23000	4697873..4699198	-	1326	WP_001352579.1	MATE family efflux transporter DinF	-
FNE84_RS23005	4699271..4699879	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	4636537..4699879	63342

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20096.62 Da
• Isoelectric Point: 4.5890

>T128471 WP_053878051.1 NZ_CP041429:c4694412-4693864 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T128471 NZ_CP041429:c4694412-4693864 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17369.87 Da
• Isoelectric Point: 7.9143

>AT128471 WP_059242328.1 NZ_CP041429:c4694908-4694435 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT128471 NZ_CP041429:c4694908-4694435 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A799QL68