Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1475226..1475851 Replicon chromosome
Accession NZ_CP041429
Organism Escherichia coli strain STEC367

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNE84_RS07110 Protein ID WP_000911330.1
Coordinates 1475453..1475851 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag FNE84_RS07105 Protein ID WP_000450524.1
Coordinates 1475226..1475453 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE84_RS07080 1471029..1471499 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
FNE84_RS07085 1471499..1472071 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
FNE84_RS07090 1472217..1473095 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
FNE84_RS07095 1473112..1474146 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
FNE84_RS07100 1474359..1475072 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FNE84_RS07105 1475226..1475453 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
FNE84_RS07110 1475453..1475851 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
FNE84_RS07115 1475998..1476861 + 864 WP_001267508.1 neutral zinc metallopeptidase -
FNE84_RS07120 1476876..1478891 + 2016 WP_000829355.1 tRNA cytosine(34) acetyltransferase TmcA -
FNE84_RS07125 1478965..1479663 + 699 WP_000679823.1 esterase -
FNE84_RS07130 1479773..1479973 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T128442 WP_000911330.1 NZ_CP041429:1475453-1475851 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T128442 NZ_CP041429:1475453-1475851 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT128442 WP_000450524.1 NZ_CP041429:1475226-1475453 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT128442 NZ_CP041429:1475226-1475453 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References