Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 863516..864351 | Replicon | chromosome |
| Accession | NZ_CP041429 | ||
| Organism | Escherichia coli strain STEC367 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W3AJH4 |
| Locus tag | FNE84_RS04145 | Protein ID | WP_000854721.1 |
| Coordinates | 863516..863893 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | FNE84_RS04150 | Protein ID | WP_161620405.1 |
| Coordinates | 863983..864351 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE84_RS04110 | 859145..859459 | - | 315 | Protein_807 | inovirus Gp2 family protein | - |
| FNE84_RS04115 | 859487..860749 | - | 1263 | WP_089643363.1 | integrase arm-type DNA-binding domain-containing protein | - |
| FNE84_RS04120 | 861213..861539 | - | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FNE84_RS04125 | 861536..861799 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FNE84_RS04130 | 861871..862737 | - | 867 | WP_161620404.1 | DUF4942 domain-containing protein | - |
| FNE84_RS04135 | 862822..863019 | - | 198 | WP_000839239.1 | DUF957 domain-containing protein | - |
| FNE84_RS04140 | 863031..863519 | - | 489 | WP_000761678.1 | hypothetical protein | - |
| FNE84_RS04145 | 863516..863893 | - | 378 | WP_000854721.1 | TA system toxin CbtA family protein | Toxin |
| FNE84_RS04150 | 863983..864351 | - | 369 | WP_161620405.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FNE84_RS04155 | 864430..864651 | - | 222 | WP_000692295.1 | DUF987 domain-containing protein | - |
| FNE84_RS04160 | 864720..865196 | - | 477 | WP_001186742.1 | RadC family protein | - |
| FNE84_RS04165 | 865212..865697 | - | 486 | WP_161623809.1 | antirestriction protein | - |
| FNE84_RS04170 | 865789..866607 | - | 819 | WP_161623810.1 | DUF945 domain-containing protein | - |
| FNE84_RS04175 | 866705..867016 | - | 312 | WP_001608658.1 | hypothetical protein | - |
| FNE84_RS04180 | 867036..867326 | - | 291 | WP_001608659.1 | hypothetical protein | - |
| FNE84_RS04185 | 867355..867633 | - | 279 | WP_001545361.1 | hypothetical protein | - |
| FNE84_RS04190 | 867895..868575 | - | 681 | WP_089581517.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH | 691915..867553 | 175638 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.12 Da Isoelectric Point: 8.2904
>T128439 WP_000854721.1 NZ_CP041429:c863893-863516 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T128439 NZ_CP041429:c863893-863516 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13609.40 Da Isoelectric Point: 6.6252
>AT128439 WP_161620405.1 NZ_CP041429:c864351-863983 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT128439 NZ_CP041429:c864351-863983 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|