Detailed information of TA system TA128438

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 803422..804257
• Replicon: chromosome
• Accession: NZ_CP041429
• Organism: Escherichia coli strain STEC367

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FNE84_RS03850
• Protein ID: WP_160520337.1
• Coordinates: 803422..803799 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FNE84_RS03855
• Protein ID: WP_061356704.1
• Coordinates: 803889..804257 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE84_RS03825	799320..799856	+	537	WP_000942798.1	GspM family type II secretion system protein YghD	-
FNE84_RS03830	800192..801727	-	1536	WP_097741818.1	EAL domain-containing protein	-
FNE84_RS03835	801798..802643	-	846	WP_097741817.1	DUF4942 domain-containing protein	-
FNE84_RS03840	802728..802925	-	198	WP_001546507.1	DUF957 domain-containing protein	-
FNE84_RS03845	802937..803425	-	489	WP_000761672.1	hypothetical protein	-
FNE84_RS03850	803422..803799	-	378	WP_160520337.1	TA system toxin CbtA family protein	Toxin
FNE84_RS03855	803889..804257	-	369	WP_061356704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FNE84_RS03860	804307..804951	-	645	WP_160520336.1	antitoxin of toxin-antitoxin stability system	-
FNE84_RS03865	804970..805191	-	222	WP_000692353.1	DUF987 domain-containing protein	-
FNE84_RS03870	805260..805736	-	477	WP_001186770.1	RadC family protein	-
FNE84_RS03875	805752..806225	-	474	WP_160520335.1	antirestriction protein	-
FNE84_RS03880	806319..806564	-	246	WP_089578131.1	antirestriction protein	-
FNE84_RS03885	806564..807382	-	819	WP_097741813.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH	691915..867553	175638

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14030.91 Da
• Isoelectric Point: 6.6303

>T128438 WP_160520337.1 NZ_CP041429:c803799-803422 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMARDNYRTVNDITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T128438 NZ_CP041429:c803799-803422 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13761.51 Da
• Isoelectric Point: 5.9618

>AT128438 WP_061356704.1 NZ_CP041429:c804257-803889 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT128438 NZ_CP041429:c804257-803889 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA