Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 778565..779400 | Replicon | chromosome |
| Accession | NZ_CP041425 | ||
| Organism | Escherichia coli strain STEC388 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3A6S2N5 |
| Locus tag | FNE85_RS03790 | Protein ID | WP_000854800.1 |
| Coordinates | 778565..778942 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3Z2YIX3 |
| Locus tag | FNE85_RS03795 | Protein ID | WP_032178229.1 |
| Coordinates | 779032..779400 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE85_RS03760 | 773964..774941 | + | 978 | WP_089584852.1 | type II secretion system minor pseudopilin GspK | - |
| FNE85_RS03765 | 774938..776125 | + | 1188 | WP_089584851.1 | type II secretion system protein GspL | - |
| FNE85_RS03770 | 776127..776663 | + | 537 | WP_032294391.1 | GspM family type II secretion system protein YghD | - |
| FNE85_RS03775 | 776944..777786 | - | 843 | WP_001290183.1 | DUF4942 domain-containing protein | - |
| FNE85_RS03780 | 777871..778068 | - | 198 | WP_001374283.1 | DUF957 domain-containing protein | - |
| FNE85_RS03785 | 778080..778568 | - | 489 | WP_000779171.1 | hypothetical protein | - |
| FNE85_RS03790 | 778565..778942 | - | 378 | WP_000854800.1 | TA system toxin CbtA family protein | Toxin |
| FNE85_RS03795 | 779032..779400 | - | 369 | WP_032178229.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FNE85_RS03800 | 779450..780094 | - | 645 | WP_161623591.1 | antitoxin of toxin-antitoxin stability system | - |
| FNE85_RS03805 | 780113..780334 | - | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| FNE85_RS03810 | 780403..780879 | - | 477 | WP_001186784.1 | RadC family protein | - |
| FNE85_RS03815 | 780894..781379 | - | 486 | WP_000213706.1 | antirestriction protein | - |
| FNE85_RS25720 | 781471..781638 | - | 168 | Protein_750 | DUF945 domain-containing protein | - |
| FNE85_RS03820 | 781670..783241 | - | 1572 | WP_161623572.1 | IS66 family transposase | - |
| FNE85_RS03825 | 783261..783608 | - | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| FNE85_RS03830 | 783608..784285 | - | 678 | WP_096101123.1 | IS66-like element accessory protein TnpA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14068.13 Da Isoelectric Point: 9.1376
>T128413 WP_000854800.1 NZ_CP041425:c778942-778565 [Escherichia coli]
MKTLPVLPGQAAGLRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDKPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKR
MKTLPVLPGQAAGLRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDKPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKR
Download Length: 378 bp
>T128413 NZ_CP041425:c778942-778565 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTTACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACGCCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATATCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACAAGCCGGGATTC
AACGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTGAACAATATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCGGTTTACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACGCCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATATCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACAAGCCGGGATTC
AACGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTGAACAATATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13823.58 Da Isoelectric Point: 6.3177
>AT128413 WP_032178229.1 NZ_CP041425:c779400-779032 [Escherichia coli]
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT128413 NZ_CP041425:c779400-779032 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3A6S2N5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2YIX3 |