Detailed information of TA system TA128404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4280270..4281314
• Replicon: chromosome
• Accession: NZ_CP041422
• Organism: Escherichia coli strain STEC409

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FNE86_RS20960
• Protein ID: WP_053878051.1
• Coordinates: 4280270..4280818 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A799QL68
• Locus tag: FNE86_RS20965
• Protein ID: WP_059242328.1
• Coordinates: 4280841..4281314 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNE86_RS20910	4275501..4276325	+	825	WP_097455378.1	YfdQ family protein	-
FNE86_RS20915	4276454..4276990	+	537	WP_000008178.1	5'-deoxynucleotidase	-
FNE86_RS20920	4276981..4277343	+	363	WP_097455379.1	hypothetical protein	-
FNE86_RS20925	4277340..4277543	+	204	WP_000111289.1	hypothetical protein	-
FNE86_RS20930	4277536..4277775	+	240	WP_000476211.1	hypothetical protein	-
FNE86_RS20935	4277772..4278026	+	255	WP_027661982.1	hypothetical protein	-
FNE86_RS20940	4278019..4278327	+	309	Protein_4098	hypothetical protein	-
FNE86_RS20945	4278393..4279355	+	963	WP_136769110.1	ead/Ea22-like family protein	-
FNE86_RS20950	4279355..4279927	+	573	WP_136769111.1	3'-5' exoribonuclease	-
FNE86_RS20955	4279964..4280236	+	273	WP_001093911.1	pyocin activator PrtN family protein	-
FNE86_RS20960	4280270..4280818	-	549	WP_053878051.1	hypothetical protein	Toxin
FNE86_RS20965	4280841..4281314	-	474	WP_059242328.1	SocA family protein	Antitoxin
FNE86_RS20970	4281602..4281724	-	123	WP_001300034.1	hypothetical protein	-
FNE86_RS20975	4282087..4283072	-	986	Protein_4105	DUF2713 domain-containing protein	-
FNE86_RS20985	4283390..4283905	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
FNE86_RS20990	4283947..4284156	-	210	WP_001030593.1	CsbD family protein	-
FNE86_RS20995	4284272..4285597	-	1326	WP_137465937.1	MATE family efflux transporter DinF	-
FNE86_RS21000	4285670..4286278	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	4229626..4286278	56652

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20096.62 Da
• Isoelectric Point: 4.5890

>T128404 WP_053878051.1 NZ_CP041422:c4280818-4280270 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T128404 NZ_CP041422:c4280818-4280270 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17369.87 Da
• Isoelectric Point: 7.9143

>AT128404 WP_059242328.1 NZ_CP041422:c4281314-4280841 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT128404 NZ_CP041422:c4281314-4280841 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A799QL68