Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2789073..2789599 | Replicon | chromosome |
| Accession | NZ_CP041422 | ||
| Organism | Escherichia coli strain STEC409 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | FNE86_RS13630 | Protein ID | WP_000323025.1 |
| Coordinates | 2789073..2789360 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | FNE86_RS13635 | Protein ID | WP_000534858.1 |
| Coordinates | 2789360..2789599 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE86_RS13585 | 2784097..2784312 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| FNE86_RS13590 | 2785066..2785281 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| FNE86_RS13595 | 2785582..2785794 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| FNE86_RS13600 | 2785849..2785938 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| FNE86_RS13605 | 2786216..2786968 | - | 753 | WP_001047135.1 | antitermination protein | - |
| FNE86_RS13610 | 2786982..2788031 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| FNE86_RS13615 | 2788033..2788311 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| FNE86_RS13620 | 2788378..2788629 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| FNE86_RS13625 | 2788846..2789001 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| FNE86_RS13630 | 2789073..2789360 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| FNE86_RS13635 | 2789360..2789599 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| FNE86_RS13640 | 2789624..2789929 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| FNE86_RS13645 | 2790132..2790464 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| FNE86_RS13650 | 2790901..2792241 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| FNE86_RS13655 | 2792275..2792694 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| FNE86_RS13660 | 2792735..2793700 | - | 966 | WP_032084229.1 | phage O protein family | - |
| FNE86_RS13665 | 2793681..2794202 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| FNE86_RS13670 | 2794186..2794413 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2756319..2819313 | 62994 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T128391 WP_000323025.1 NZ_CP041422:c2789360-2789073 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T128391 NZ_CP041422:c2789360-2789073 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT128391 WP_000534858.1 NZ_CP041422:c2789599-2789360 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT128391 NZ_CP041422:c2789599-2789360 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|