Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 34523..35070 Replicon plasmid pSTEC711_4
Accession NZ_CP041420
Organism Escherichia coli strain STEC711

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag FNE87_RS24600 Protein ID WP_000969996.1
Coordinates 34523..34804 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag FNE87_RS24605 Protein ID WP_000079928.1
Coordinates 34801..35070 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE87_RS24565 29631..30557 + 927 WP_001290416.1 hypothetical protein -
FNE87_RS24570 30602..30857 + 256 Protein_44 hypothetical protein -
FNE87_RS24575 31356..31700 + 345 WP_000793307.1 hypothetical protein -
FNE87_RS24580 31876..32877 - 1002 WP_000774874.1 DUF4238 domain-containing protein -
FNE87_RS24585 33229..33483 + 255 WP_000343103.1 hypothetical protein -
FNE87_RS24590 33483..34073 + 591 WP_000194550.1 hypothetical protein -
FNE87_RS24595 34091..34438 - 348 WP_001115718.1 hypothetical protein -
FNE87_RS24600 34523..34804 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNE87_RS24605 34801..35070 - 270 WP_000079928.1 hypothetical protein Antitoxin
FNE87_RS24610 35983..36840 - 858 WP_161620435.1 incFII family plasmid replication initiator RepA -
FNE87_RS24615 36833..36907 - 75 WP_001375168.1 RepA leader peptide Tap -
FNE87_RS24620 37131..37391 - 261 WP_000083819.1 replication regulatory protein RepA -
FNE87_RS24625 37561..37758 - 198 WP_149004681.1 type I toxin-antitoxin system Hok family toxin -
FNE87_RS24630 37835..38830 - 996 WP_000118344.1 hypothetical protein -
FNE87_RS24635 38936..39220 - 285 WP_053893889.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..65701 65701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T128376 WP_000969996.1 NZ_CP041420:c34804-34523 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T128376 NZ_CP041420:c34804-34523 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCACATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT128376 WP_000079928.1 NZ_CP041420:c35070-34801 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT128376 NZ_CP041420:c35070-34801 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGATCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGCGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCATCTGCTGCAGCATGGAGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References