Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2855928..2856399 | Replicon | chromosome |
| Accession | NZ_CP041416 | ||
| Organism | Escherichia coli strain STEC711 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | FNE87_RS13965 | Protein ID | WP_001303511.1 |
| Coordinates | 2856121..2856399 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | FNE87_RS13960 | Protein ID | WP_001302048.1 |
| Coordinates | 2855928..2856119 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE87_RS13905 | 2851092..2851457 | - | 366 | WP_001229294.1 | HNH endonuclease | - |
| FNE87_RS13910 | 2851459..2851677 | - | 219 | WP_161620344.1 | DUF4014 family protein | - |
| FNE87_RS13915 | 2851710..2851922 | - | 213 | WP_161620345.1 | hypothetical protein | - |
| FNE87_RS13920 | 2851973..2852473 | - | 501 | WP_161620346.1 | ead/Ea22-like family protein | - |
| FNE87_RS13925 | 2852460..2852726 | - | 267 | WP_161620347.1 | hypothetical protein | - |
| FNE87_RS13930 | 2852723..2853118 | - | 396 | WP_161620348.1 | DUF977 family protein | - |
| FNE87_RS13935 | 2853148..2853690 | - | 543 | WP_161620349.1 | replication protein | - |
| FNE87_RS13940 | 2853602..2854642 | - | 1041 | WP_161620350.1 | phage replisome organizer | - |
| FNE87_RS13945 | 2854714..2855139 | - | 426 | WP_161620351.1 | Rha family transcriptional regulator | - |
| FNE87_RS13950 | 2855136..2855438 | - | 303 | WP_000172735.1 | transcriptional regulator | - |
| FNE87_RS13955 | 2855536..2855907 | + | 372 | WP_122985828.1 | hypothetical protein | - |
| FNE87_RS13960 | 2855928..2856119 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| FNE87_RS13965 | 2856121..2856399 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FNE87_RS13970 | 2856691..2856846 | + | 156 | WP_000379589.1 | DUF1391 family protein | - |
| FNE87_RS13975 | 2857006..2857224 | + | 219 | WP_086590109.1 | hypothetical protein | - |
| FNE87_RS13980 | 2857247..2857653 | + | 407 | Protein_2744 | hypothetical protein | - |
| FNE87_RS13985 | 2857631..2857864 | - | 234 | WP_000920491.1 | hypothetical protein | - |
| FNE87_RS13990 | 2858432..2858620 | + | 189 | WP_033560808.1 | cell division inhibition protein DicB | - |
| FNE87_RS13995 | 2858617..2858820 | + | 204 | WP_001090193.1 | DUF1482 family protein | - |
| FNE87_RS14000 | 2858901..2861381 | + | 2481 | WP_161620352.1 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T128367 WP_001303511.1 NZ_CP041416:2856121-2856399 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T128367 NZ_CP041416:2856121-2856399 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT128367 WP_001302048.1 NZ_CP041416:2855928-2856119 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT128367 NZ_CP041416:2855928-2856119 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|