Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 853172..854007 | Replicon | chromosome |
| Accession | NZ_CP041416 | ||
| Organism | Escherichia coli strain STEC711 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W3AJH4 |
| Locus tag | FNE87_RS04040 | Protein ID | WP_000854721.1 |
| Coordinates | 853172..853549 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | FNE87_RS04045 | Protein ID | WP_161620405.1 |
| Coordinates | 853639..854007 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE87_RS04010 | 849143..850405 | - | 1263 | WP_001218875.1 | integrase arm-type DNA-binding domain-containing protein | - |
| FNE87_RS04015 | 850869..851195 | - | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FNE87_RS04020 | 851192..851455 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FNE87_RS04025 | 851527..852393 | - | 867 | WP_161620404.1 | DUF4942 domain-containing protein | - |
| FNE87_RS04030 | 852478..852675 | - | 198 | WP_000839239.1 | DUF957 domain-containing protein | - |
| FNE87_RS04035 | 852687..853175 | - | 489 | WP_000761678.1 | hypothetical protein | - |
| FNE87_RS04040 | 853172..853549 | - | 378 | WP_000854721.1 | TA system toxin CbtA family protein | Toxin |
| FNE87_RS04045 | 853639..854007 | - | 369 | WP_161620405.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FNE87_RS04050 | 854086..854307 | - | 222 | WP_000692295.1 | DUF987 domain-containing protein | - |
| FNE87_RS04055 | 854376..854852 | - | 477 | WP_001186742.1 | RadC family protein | - |
| FNE87_RS04060 | 854868..855353 | - | 486 | WP_000206660.1 | antirestriction protein | - |
| FNE87_RS04065 | 855445..856263 | - | 819 | WP_097331407.1 | DUF945 domain-containing protein | - |
| FNE87_RS04070 | 856361..856672 | - | 312 | WP_001608658.1 | hypothetical protein | - |
| FNE87_RS04075 | 856692..856982 | - | 291 | WP_001608659.1 | hypothetical protein | - |
| FNE87_RS04080 | 857011..857289 | - | 279 | WP_001545361.1 | hypothetical protein | - |
| FNE87_RS04085 | 857551..858231 | - | 681 | WP_089581517.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 819862..865302 | 45440 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.12 Da Isoelectric Point: 8.2904
>T128350 WP_000854721.1 NZ_CP041416:c853549-853172 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T128350 NZ_CP041416:c853549-853172 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGTTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13609.40 Da Isoelectric Point: 6.6252
>AT128350 WP_161620405.1 NZ_CP041416:c854007-853639 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT128350 NZ_CP041416:c854007-853639 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGTGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|