Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 788432..789230 Replicon chromosome
Accession NZ_CP041416
Organism Escherichia coli strain STEC711

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FNE87_RS03775 Protein ID WP_072713924.1
Coordinates 788432..788809 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FNE87_RS03780 Protein ID WP_072713922.1
Coordinates 788856..789230 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE87_RS03745 784324..784860 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
FNE87_RS03750 785195..786730 - 1536 WP_096858932.1 EAL domain-containing protein -
FNE87_RS25245 786801..787649 - 849 Protein_734 DUF4942 domain-containing protein -
FNE87_RS03765 787738..787935 - 198 WP_000839243.1 DUF957 domain-containing protein -
FNE87_RS03770 787947..788435 - 489 WP_072713926.1 hypothetical protein -
FNE87_RS03775 788432..788809 - 378 WP_072713924.1 TA system toxin CbtA family protein Toxin
FNE87_RS03780 788856..789230 - 375 WP_072713922.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FNE87_RS03785 789280..789924 - 645 WP_161620209.1 antitoxin of toxin-antitoxin stability system -
FNE87_RS03790 789943..790164 - 222 WP_000692326.1 DUF987 domain-containing protein -
FNE87_RS03795 790227..790703 - 477 WP_122996610.1 RadC family protein -
FNE87_RS03800 790719..791204 - 486 WP_000206671.1 antirestriction protein -
FNE87_RS03805 791296..792114 - 819 WP_161620210.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14261.29 Da        Isoelectric Point: 7.2922

>T128349 WP_072713924.1 NZ_CP041416:c788809-788432 [Escherichia coli]
MKTLPDTHVREASRCLSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLITRDNYRKVNDITLGKHPEAKQ

Download         Length: 378 bp

>T128349 NZ_CP041416:c788809-788432 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCTGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATAACCCGCGA
CAACTACAGAAAGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14039.87 Da        Isoelectric Point: 6.4772

>AT128349 WP_072713922.1 NZ_CP041416:c789230-788856 [Escherichia coli]
VSDKLHETNYPDDHNDRIWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARELTCEADSLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT128349 NZ_CP041416:c789230-788856 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCATCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGAGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References