Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 19587..20134 Replicon plasmid pSTEC719_4
Accession NZ_CP041415
Organism Escherichia coli strain STEC719

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag FNE88_RS25370 Protein ID WP_000969996.1
Coordinates 19853..20134 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag FNE88_RS25365 Protein ID WP_000079941.1
Coordinates 19587..19856 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE88_RS25335 14634..15116 + 483 WP_001523473.1 hypothetical protein -
FNE88_RS25340 15109..15966 + 858 WP_161622518.1 incFII family plasmid replication initiator RepA -
FNE88_RS25345 16137..16814 + 678 WP_001339397.1 IS66 family insertion sequence hypothetical protein -
FNE88_RS25350 16814..17161 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
FNE88_RS25355 17181..18752 + 1572 WP_000381395.1 IS66 family transposase -
FNE88_RS25365 19587..19856 + 270 WP_000079941.1 hypothetical protein Antitoxin
FNE88_RS25370 19853..20134 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNE88_RS25375 20398..21570 + 1173 WP_161622519.1 hypothetical protein -
FNE88_RS25380 21673..22584 + 912 WP_136769172.1 toll/interleukin-1 receptor domain-containing protein -
FNE88_RS25385 22726..23121 - 396 WP_096934596.1 plasmid partitioning/stability family protein -
FNE88_RS25390 23121..23671 - 551 Protein_25 plasmid stabilization protein -
FNE88_RS25395 23665..23886 + 222 WP_077775928.1 hypothetical protein -
FNE88_RS25400 23908..24243 - 336 WP_161620440.1 colicin transporter -
FNE88_RS25405 24372..24719 + 348 WP_033812875.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85426 85426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T128340 WP_000969996.1 NZ_CP041415:19853-20134 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T128340 NZ_CP041415:19853-20134 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCTGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT128340 WP_000079941.1 NZ_CP041415:19587-19856 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT128340 NZ_CP041415:19587-19856 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References