Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3165943..3166414 | Replicon | chromosome |
| Accession | NZ_CP041411 | ||
| Organism | Escherichia coli strain STEC719 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | FNE88_RS15770 | Protein ID | WP_001303511.1 |
| Coordinates | 3166136..3166414 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | FNE88_RS15765 | Protein ID | WP_001302048.1 |
| Coordinates | 3165943..3166134 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNE88_RS15710 | 3161107..3161472 | - | 366 | WP_001229294.1 | HNH endonuclease | - |
| FNE88_RS15715 | 3161474..3161692 | - | 219 | WP_161620344.1 | DUF4014 family protein | - |
| FNE88_RS15720 | 3161725..3161937 | - | 213 | WP_161620345.1 | hypothetical protein | - |
| FNE88_RS15725 | 3161988..3162488 | - | 501 | WP_161620346.1 | ead/Ea22-like family protein | - |
| FNE88_RS15730 | 3162475..3162741 | - | 267 | WP_161620347.1 | hypothetical protein | - |
| FNE88_RS15735 | 3162738..3163133 | - | 396 | WP_161620348.1 | DUF977 family protein | - |
| FNE88_RS15740 | 3163163..3163705 | - | 543 | WP_161622456.1 | replication protein | - |
| FNE88_RS15745 | 3163617..3164657 | - | 1041 | WP_161620350.1 | phage replisome organizer | - |
| FNE88_RS15750 | 3164729..3165154 | - | 426 | WP_161620351.1 | Rha family transcriptional regulator | - |
| FNE88_RS15755 | 3165151..3165453 | - | 303 | WP_000172735.1 | transcriptional regulator | - |
| FNE88_RS15760 | 3165551..3165922 | + | 372 | WP_122985828.1 | hypothetical protein | - |
| FNE88_RS15765 | 3165943..3166134 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| FNE88_RS15770 | 3166136..3166414 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FNE88_RS15775 | 3166706..3166861 | + | 156 | WP_000379589.1 | DUF1391 family protein | - |
| FNE88_RS15780 | 3167021..3167239 | + | 219 | WP_086590109.1 | hypothetical protein | - |
| FNE88_RS15785 | 3167262..3167668 | + | 407 | Protein_3104 | hypothetical protein | - |
| FNE88_RS15790 | 3167646..3167879 | - | 234 | WP_000920491.1 | hypothetical protein | - |
| FNE88_RS15795 | 3168447..3168635 | + | 189 | WP_033560808.1 | cell division inhibition protein DicB | - |
| FNE88_RS15800 | 3168632..3168835 | + | 204 | WP_001090193.1 | DUF1482 family protein | - |
| FNE88_RS15805 | 3168916..3171396 | + | 2481 | WP_161620352.1 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T128325 WP_001303511.1 NZ_CP041411:3166136-3166414 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T128325 NZ_CP041411:3166136-3166414 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT128325 WP_001302048.1 NZ_CP041411:3165943-3166134 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT128325 NZ_CP041411:3165943-3166134 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|