Detailed information of TA system TA128263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 385030..385604
• Replicon: chromosome
• Accession: NZ_CP041387
• Organism: Rhodopseudomonas palustris strain GJ-22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FLL57_RS01805
• Protein ID: WP_047308981.1
• Coordinates: 385236..385604 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A336JL66
• Locus tag: FLL57_RS01800
• Protein ID: WP_047308980.1
• Coordinates: 385030..385236 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLL57_RS01765	381011..381757	+	747	WP_013501043.1	YebC/PmpR family DNA-binding transcriptional regulator	-
FLL57_RS01770	382032..382553	+	522	WP_047307674.1	crossover junction endodeoxyribonuclease RuvC	-
FLL57_RS01780	382720..383337	+	618	WP_142881970.1	Holliday junction branch migration protein RuvA	-
FLL57_RS01785	383334..383759	+	426	WP_142881971.1	cytidine deaminase	-
FLL57_RS01795	383928..384971	+	1044	WP_142881972.1	Holliday junction branch migration DNA helicase RuvB	-
FLL57_RS01800	385030..385236	+	207	WP_047308980.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FLL57_RS01805	385236..385604	+	369	WP_047308981.1	type II toxin-antitoxin system VapC family toxin	Toxin
FLL57_RS01810	385609..386055	+	447	WP_013501049.1	tol-pal system-associated acyl-CoA thioesterase	-
FLL57_RS01815	386153..387463	+	1311	WP_013501050.1	NAD(P)/FAD-dependent oxidoreductase	-
FLL57_RS01820	387574..388824	+	1251	WP_142881973.1	OpgC domain-containing protein	-
FLL57_RS01825	388882..389349	+	468	WP_013501052.1	nuclear transport factor 2 family protein	-
FLL57_RS01830	389368..389913	+	546	WP_013501053.1	TetR/AcrR family transcriptional regulator	-
FLL57_RS01835	390104..390475	+	372	WP_142884146.1	YciI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13211.19 Da
• Isoelectric Point: 5.1123

>T128263 WP_047308981.1 NZ_CP041387:385236-385604 [Rhodopseudomonas palustris]
MLLVDTSIWIDHFRKGDSTLSAALGREEVLVHAFVLGELALGHNVHFEMIATDLSDLPQATIAVPGEVLRLISRAELAGS
GIGYVDAHLVASTLLTPEAQLWTRDKRLKAVADRLSISAQVE

Nucleotide

• Length: 369 bp

>T128263 NZ_CP041387:385236-385604 [Rhodopseudomonas palustris]
ATGCTCCTGGTCGACACATCGATCTGGATCGACCATTTCCGCAAGGGAGACTCGACGCTCAGCGCCGCTCTTGGTCGGGA
AGAGGTCCTGGTCCATGCTTTTGTTCTGGGCGAGTTAGCGCTGGGCCATAACGTTCACTTTGAGATGATCGCGACCGACC
TTTCGGACCTTCCTCAAGCGACGATTGCGGTGCCTGGTGAGGTATTGCGGCTCATTTCGCGCGCCGAGCTGGCCGGCTCG
GGAATCGGCTACGTGGATGCACATCTAGTCGCTTCGACGCTGCTGACGCCTGAGGCGCAGCTATGGACGCGCGATAAGAG
ATTAAAAGCGGTGGCCGATCGACTATCGATCTCCGCCCAAGTGGAGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7565.72 Da
• Isoelectric Point: 10.8025

>AT128263 WP_047308980.1 NZ_CP041387:385030-385236 [Rhodopseudomonas palustris]
MRTTIAIDDELFAKAQKFAGLDEKSAVIKTALQAYVEREAARRLARMGGSMPDAKAPPRRRSPKFTND

Nucleotide

• Length: 207 bp

>AT128263 NZ_CP041387:385030-385236 [Rhodopseudomonas palustris]
ATGAGAACGACGATTGCCATCGACGATGAGTTGTTTGCGAAAGCTCAGAAATTTGCAGGCCTCGACGAAAAGTCCGCAGT
GATCAAGACGGCGCTGCAGGCCTATGTCGAACGTGAAGCAGCGAGGCGACTTGCGCGCATGGGTGGGTCGATGCCCGATG
CCAAGGCGCCCCCGCGTCGGCGCTCACCCAAATTCACCAACGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A336JL66