Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4925711..4926227 Replicon chromosome
Accession NZ_CP041373
Organism Klebsiella pneumoniae strain KP58

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FM021_RS24625 Protein ID WP_002886902.1
Coordinates 4925711..4925995 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FM021_RS24630 Protein ID WP_002886901.1
Coordinates 4925985..4926227 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FM021_RS24605 4921195..4921503 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
FM021_RS30700 4921588..4921761 + 174 WP_002886906.1 hypothetical protein -
FM021_RS24610 4921764..4922507 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FM021_RS24615 4922864..4925002 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FM021_RS24620 4925243..4925707 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FM021_RS24625 4925711..4925995 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FM021_RS24630 4925985..4926227 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FM021_RS24635 4926305..4928215 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FM021_RS24640 4928238..4929392 - 1155 WP_002886900.1 lactonase family protein -
FM021_RS24645 4929458..4930198 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T128250 WP_002886902.1 NZ_CP041373:c4925995-4925711 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T128250 NZ_CP041373:c4925995-4925711 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT128250 WP_002886901.1 NZ_CP041373:c4926227-4925985 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT128250 NZ_CP041373:c4926227-4925985 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References