Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877299..877953 Replicon chromosome
Accession NZ_CP041373
Organism Klebsiella pneumoniae strain KP58

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag FM021_RS04450 Protein ID WP_004144731.1
Coordinates 877546..877953 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FM021_RS04445 Protein ID WP_002916312.1
Coordinates 877299..877565 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FM021_RS04420 872455..873888 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FM021_RS04425 874007..874735 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FM021_RS04430 874785..875096 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FM021_RS04435 875260..875919 + 660 WP_002916317.1 hemolysin III family protein -
FM021_RS04440 876070..877053 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FM021_RS04445 877299..877565 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FM021_RS04450 877546..877953 + 408 WP_004144731.1 protein YgfX Toxin
FM021_RS04455 877960..878481 - 522 WP_002916308.1 flavodoxin FldB -
FM021_RS04460 878582..879478 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FM021_RS04465 879501..880214 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FM021_RS04470 880220..881953 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T128238 WP_004144731.1 NZ_CP041373:877546-877953 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T128238 NZ_CP041373:877546-877953 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT128238 WP_002916312.1 NZ_CP041373:877299-877565 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT128238 NZ_CP041373:877299-877565 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References