Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 696804..697438 Replicon chromosome
Accession NZ_CP041372
Organism Bacillus sp. M4U3P1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag FLK61_RS03955 Protein ID WP_176008232.1
Coordinates 697088..697438 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag FLK61_RS03950 Protein ID WP_176008231.1
Coordinates 696804..697082 (+) Length 93 a.a.

Genomic Context

FLK61_RS03935FLK61_RS03940FLK61_RS03945FLK61_RS03950FLK61_RS03955FLK61_RS03960FLK61_RS03965FLK61_RS03970FLK61_RS03975FLK61_RS03980FLK61_RS03985FLK61_RS03990FLK61_RS03930
Location: 693192..693545 (354 bp)
Type: Others
Protein ID: WP_176008228.1
Location: 693605..694825 (1221 bp)
Type: Others
Protein ID: WP_176008229.1
Location: 695344..696552 (1209 bp)
Type: Others
Protein ID: WP_176008230.1
Location: 696804..697082 (279 bp)
Type: Antitoxin
Protein ID: WP_176008231.1
Location: 697088..697438 (351 bp)
Type: Toxin
Protein ID: WP_176008232.1
Location: 697597..698424 (828 bp)
Type: Others
Protein ID: WP_176008233.1
Location: 698436..698792 (357 bp)
Type: Others
Protein ID: WP_176008234.1
Location: 698795..699196 (402 bp)
Type: Others
Protein ID: WP_176008235.1
Location: 699221..700225 (1005 bp)
Type: Others
Protein ID: WP_176011130.1
Location: 700291..700620 (330 bp)
Type: Others
Protein ID: WP_176008236.1
Location: 700623..701114 (492 bp)
Type: Others
Protein ID: WP_176011131.1
Location: 701077..701880 (804 bp)
Type: Others
Protein ID: WP_176008237.1
Location: 692332..693087 (756 bp)
Type: Others
Protein ID: WP_176011129.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FLK61_RS03930692332..693087-756WP_176011129.1rhomboid family intramembrane serine protease-
FLK61_RS03935693192..693545+354WP_176008228.1holo-ACP synthase-
FLK61_RS03940693605..694825+1221WP_176008229.1outer membrane lipoprotein carrier protein LolA-
FLK61_RS03945695344..696552+1209WP_176008230.1alanine racemase-
FLK61_RS03950696804..697082+279WP_176008231.1antitoxinAntitoxin
FLK61_RS03955697088..697438+351WP_176008232.1type II toxin-antitoxin system PemK/MazF family toxinToxin
FLK61_RS03960697597..698424+828WP_176008233.1STAS domain-containing protein-
FLK61_RS03965698436..698792+357WP_176008234.1STAS domain-containing protein-
FLK61_RS03970698795..699196+402WP_176008235.1anti-sigma regulatory factor-
FLK61_RS03975699221..700225+1005WP_176011130.1PP2C family protein-serine/threonine phosphatase-
FLK61_RS03980700291..700620+330WP_176008236.1STAS domain-containing protein-
FLK61_RS03985700623..701114+492WP_176011131.1anti-sigma B factor RsbW-
FLK61_RS03990701077..701880+804WP_176008237.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12903.94 Da        Isoelectric Point: 5.6825

>T128234 WP_176008232.1 NZ_CP041372:697088-697438 [Bacillus sp. M4U3P1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKQYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDDMMLKVNDALNISIGLIDF

Download         Length: 351 bp

>T128234 NZ_CP041372:697088-697438 [Bacillus sp. M4U3P1]
TTGATAGTCAAACGCGGTGATGTTTATTTTGCAGACTTATCACCAGTCGTTGGGTCAGAGCAGGGAGGAGTAAGACCTGT
TTTGATCGTACAAAACGACATTGGGAACAGATTTAGCCCAACGGTGATTGTTGCAGCAATTACAGCACAAATTCAAAAAG
CAAAACTACCAACACACGTAGAGATCAACGCTAAGCAATACGGATTTGATCGCGACTCGGTCATTTTATTAGAACAAATC
CGCACGATTGACAAACAACGATTAACAGACAAAATTACTCATTTAGATGACGATATGATGTTAAAAGTGAATGACGCATT
GAACATAAGCATTGGCCTTATTGACTTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10485.97 Da        Isoelectric Point: 4.2298

>AT128234 WP_176008231.1 NZ_CP041372:696804-697082 [Bacillus sp. M4U3P1]
VSMESTKNITVSLPQQLVNELDALTEGKDEDRCAFIQRATKMYVQEQKKLLIRETMQQGYEEMAKINLMIATESFLVEEE
AESTLDRLVSGV

Download         Length: 279 bp

>AT128234 NZ_CP041372:696804-697082 [Bacillus sp. M4U3P1]
GTGTCTATGGAAAGTACAAAGAACATTACGGTTAGTTTACCGCAACAATTGGTGAATGAATTAGATGCATTAACAGAAGG
TAAAGATGAAGATCGCTGCGCATTTATCCAACGTGCAACAAAAATGTACGTGCAGGAGCAAAAGAAGCTACTCATTCGCG
AGACGATGCAACAGGGGTACGAAGAAATGGCGAAAATCAACTTAATGATTGCAACGGAATCCTTTTTAGTTGAAGAGGAG
GCTGAAAGTACGCTAGATCGCCTTGTTAGTGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References