Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3938097..3938673 Replicon chromosome
Accession NZ_CP041362
Organism Citrobacter amalonaticus strain 133355-SW-C4-Cam

Toxin (Protein)


Gene name shpA Uniprot ID A0A8B3ZLZ2
Locus tag FEO47_RS18825 Protein ID WP_044326916.1
Coordinates 3938386..3938673 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A8B3ZM28
Locus tag FEO47_RS18820 Protein ID WP_044326917.1
Coordinates 3938097..3938399 (-) Length 101 a.a.

Genomic Context

FEO47_RS18805FEO47_RS18810FEO47_RS18815FEO47_RS18830FEO47_RS18835FEO47_RS18800FEO47_RS18820FEO47_RS18825
Location: 3934595..3936745 (2151 bp)
Type: Others
Protein ID: WP_042321961.1
Location: 3936853..3937056 (204 bp)
Type: Others
Protein ID: WP_024130742.1
Location: 3937069..3938028 (960 bp)
Type: Others
Protein ID: WP_044253881.1
Location: 3939028..3941370 (2343 bp)
Type: Others
Protein ID: WP_090048357.1
Location: 3941370..3942767 (1398 bp)
Type: Others
Protein ID: WP_090048356.1
Location: 3933291..3934298 (1008 bp)
Type: Others
Protein ID: WP_044264468.1
Location: 3938097..3938399 (303 bp)
Type: Antitoxin
Protein ID: WP_044326917.1
Location: 3938386..3938673 (288 bp)
Type: Toxin
Protein ID: WP_044326916.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FEO47_RS188003933291..3934298-1008WP_044264468.1Ldh family oxidoreductase-
FEO47_RS188053934595..3936745+2151WP_042321961.1pyruvate/proton symporter BtsT-
FEO47_RS188103936853..3937056+204WP_024130742.1YbdD/YjiX family protein-
FEO47_RS188153937069..3938028+960WP_044253881.1GTPase-
FEO47_RS188203938097..3938399-303WP_044326917.1BrnA antitoxin family proteinAntitoxin
FEO47_RS188253938386..3938673-288WP_044326916.1BrnT family toxinToxin
FEO47_RS188303939028..3941370+2343WP_090048357.1type I restriction-modification system subunit M-
FEO47_RS188353941370..3942767+1398WP_090048356.1restriction endonuclease subunit S-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11095.53 Da        Isoelectric Point: 8.6574

>T128223 WP_044326916.1 NZ_CP041362:c3938673-3938386 [Citrobacter amalonaticus]
MPTEFEWDANKARSNVGKHGVRFEDAILVFDDPRHLSRQDRIENGEYRWQTLGLVHGIVVILVAHSIRFESGIDVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T128223 NZ_CP041362:c3938673-3938386 [Citrobacter amalonaticus]
ATGCCAACGGAGTTTGAATGGGATGCAAATAAGGCAAGAAGCAATGTCGGTAAACATGGTGTCCGTTTTGAAGATGCGAT
TCTGGTATTTGACGATCCACGACATCTTTCACGACAGGATCGCATAGAGAACGGGGAATATCGCTGGCAAACCCTCGGTC
TCGTTCATGGCATCGTAGTCATTCTGGTTGCTCACAGCATTCGGTTTGAAAGTGGTATCGATGTCATTCGCATCATCAGC
GCCAGAAAGGCGGATCGTAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11460.05 Da        Isoelectric Point: 10.1293

>AT128223 WP_044326917.1 NZ_CP041362:c3938399-3938097 [Citrobacter amalonaticus]
MSMVKHKRGAQSSLSAQHEAELKALAKKSDDEIDYSDIPSSPDEQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT128223 NZ_CP041362:c3938399-3938097 [Citrobacter amalonaticus]
ATGAGCATGGTTAAACATAAACGCGGCGCGCAATCCTCGCTCAGTGCTCAGCATGAGGCGGAACTCAAAGCGTTGGCGAA
GAAATCAGATGATGAAATTGATTACAGTGATATCCCCTCTTCGCCAGATGAGCAATGGTCTGAAGCAGTACGCGGTAAGT
TTTTTCGCCCGCTAAAAACCCAGGCGTCCGTACGTATTGACGCGGATGTGATGGAATGGCTGAAGCGTCCGGGGAAAGGG
TATCAGACACGGCTTAACGCGATCTTGCGGGAAGCGATGCTGCGGGAACAAAACAAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B3ZLZ2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8B3ZM28

References