Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3869047..3869701 Replicon chromosome
Accession NZ_CP041362
Organism Citrobacter amalonaticus strain 133355-SW-C4-Cam

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag FEO47_RS18465 Protein ID WP_044254016.1
Coordinates 3869047..3869454 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag FEO47_RS18470 Protein ID WP_042322123.1
Coordinates 3869435..3869701 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEO47_RS18445 3864952..3866685 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
FEO47_RS18450 3866691..3867404 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FEO47_RS18455 3867428..3868324 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
FEO47_RS18460 3868425..3868946 + 522 WP_042999366.1 flavodoxin FldB -
FEO47_RS18465 3869047..3869454 - 408 WP_044254016.1 protein YgfX Toxin
FEO47_RS18470 3869435..3869701 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
FEO47_RS18475 3869958..3870938 + 981 WP_042999364.1 tRNA-modifying protein YgfZ -
FEO47_RS18480 3871019..3871678 - 660 WP_044264418.1 hemolysin III family protein -
FEO47_RS18485 3871841..3872152 - 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
FEO47_RS18490 3872205..3872933 + 729 WP_142765507.1 MurR/RpiR family transcriptional regulator -
FEO47_RS18495 3873053..3874486 + 1434 WP_042999360.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T128222 WP_044254016.1 NZ_CP041362:c3869454-3869047 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T128222 NZ_CP041362:c3869454-3869047 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCTATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGACTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCAGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGGGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT128222 WP_042322123.1 NZ_CP041362:c3869701-3869435 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT128222 NZ_CP041362:c3869701-3869435 [Citrobacter amalonaticus]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References