Detailed information of TA system TA128206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 7122156..7122730
• Replicon: chromosome
• Accession: NZ_CP041360
• Organism: Spirosoma sp. KCTC 42546

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EXU85_RS29115
• Protein ID: WP_142775447.1
• Coordinates: 7122156..7122485 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EXU85_RS29120
• Protein ID: WP_142775448.1
• Coordinates: 7122473..7122730 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXU85_RS29110	7117724..7122073	+	4350	WP_142775446.1	DNA-directed RNA polymerase subunit beta'	-
EXU85_RS29115	7122156..7122485	-	330	WP_142775447.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EXU85_RS29120	7122473..7122730	-	258	WP_142775448.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EXU85_RS29125	7122871..7125732	-	2862	WP_142775449.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-106)

Antitoxin

• SpoVT-AbrB domain (6-48)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12180.11 Da
• Isoelectric Point: 8.2646

>T128206 WP_142775447.1 NZ_CP041360:c7122485-7122156 [Spirosoma sp. KCTC 42546]
MAVVISRFEVWLVSLDPTRGSEIAKTRPCVVISPDSVNKYLNTVIIAPLTSAHKPYPTRVDCQFDGRVGQIALDQERSVD
KSRLVKKLGRLDEAANQQICATLVEMFTY

Nucleotide

• Length: 330 bp

>T128206 NZ_CP041360:c7122485-7122156 [Spirosoma sp. KCTC 42546]
ATGGCAGTGGTAATTAGTCGCTTCGAAGTTTGGTTGGTGTCTTTAGATCCAACTCGGGGTAGCGAAATTGCCAAAACACG
TCCCTGTGTAGTTATTTCGCCGGATTCGGTAAACAAGTATCTAAATACGGTTATTATTGCTCCCCTAACCAGTGCTCATA
AGCCCTATCCAACACGAGTCGATTGTCAGTTCGATGGTCGGGTTGGCCAGATAGCACTAGATCAGGAGCGGAGTGTGGAT
AAATCGCGTTTAGTAAAAAAGCTTGGGCGGTTAGACGAAGCTGCAAACCAACAAATTTGCGCTACGTTAGTAGAAATGTT
TACGTATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9660.81 Da
• Isoelectric Point: 4.5368

>AT128206 WP_142775448.1 NZ_CP041360:c7122730-7122473 [Spirosoma sp. KCTC 42546]
MQVHIRRIGNSQGIILPRPLLQQAGIENEVDLEVIDGAIVLRPAKSDPRANWDQLFQNAIEAGHKPEKDLFNGASNDFDQ
TEWQW

Nucleotide

• Length: 258 bp

>AT128206 NZ_CP041360:c7122730-7122473 [Spirosoma sp. KCTC 42546]
ATGCAAGTACATATCAGACGTATCGGTAATTCTCAGGGCATTATTCTTCCAAGACCTTTACTTCAACAGGCGGGTATTGA
AAATGAGGTTGACTTGGAGGTAATAGATGGTGCTATTGTTCTTCGCCCTGCGAAGTCAGACCCTCGTGCTAATTGGGATC
AACTGTTTCAGAATGCGATTGAAGCTGGTCATAAGCCTGAGAAAGACTTGTTTAACGGTGCATCGAATGATTTTGATCAA
ACCGAATGGCAGTGGTAA