Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5621693..5622300 Replicon chromosome
Accession NZ_CP041360
Organism Spirosoma sp. KCTC 42546

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EXU85_RS23125 Protein ID WP_142774356.1
Coordinates 5621693..5622088 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EXU85_RS23130 Protein ID WP_142774357.1
Coordinates 5622085..5622300 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXU85_RS23105 5617298..5618053 + 756 WP_111349440.1 hypothetical protein -
EXU85_RS23110 5618142..5619605 + 1464 WP_142774353.1 tetratricopeptide repeat protein -
EXU85_RS23115 5619669..5620154 - 486 WP_168207853.1 hypothetical protein -
EXU85_RS23120 5620424..5621611 - 1188 WP_142774355.1 phosphoglycerate kinase -
EXU85_RS23125 5621693..5622088 - 396 WP_142774356.1 PIN domain nuclease Toxin
EXU85_RS23130 5622085..5622300 - 216 WP_142774357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EXU85_RS23135 5622344..5623534 - 1191 WP_142774358.1 hypothetical protein -
EXU85_RS23140 5623521..5624498 - 978 WP_142774359.1 DUF2157 domain-containing protein -
EXU85_RS23145 5624529..5626217 + 1689 WP_142774360.1 VRR-NUC domain-containing protein -
EXU85_RS23150 5626330..5626731 + 402 WP_142774361.1 DUF1801 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-45)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15006.53 Da        Isoelectric Point: 6.4736

>T128205 WP_142774356.1 NZ_CP041360:c5622088-5621693 [Spirosoma sp. KCTC 42546]
MIIDTSVWIDFFRDVQSAQTDLLVELLLAKERLCITPTILQEVLQGVHADNHFERIKTDLLACRMLQIDPVKAAIEAATL
YRTLRKKGVTIRKPNDCLIAHYAIFYDIPVLHNDIDFDQIARFTALRIANA

Download         Length: 396 bp

>T128205 NZ_CP041360:c5622088-5621693 [Spirosoma sp. KCTC 42546]
ATGATTATTGATACATCCGTTTGGATAGATTTTTTTAGGGATGTTCAGAGTGCGCAGACAGATTTATTAGTCGAACTCCT
GCTTGCGAAGGAGAGGCTGTGTATTACACCTACGATACTGCAGGAAGTCTTACAGGGAGTACATGCTGATAATCATTTTG
AACGAATAAAAACCGACCTATTAGCCTGTCGCATGTTACAGATTGACCCTGTTAAAGCCGCTATTGAAGCGGCAACGTTA
TACCGAACTCTTCGCAAAAAAGGGGTAACGATTCGTAAACCCAACGATTGTTTGATTGCTCATTACGCCATATTCTACGA
TATTCCTGTTCTGCATAACGATATCGACTTTGACCAAATCGCGCGCTTTACCGCATTACGTATTGCCAACGCGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8403.67 Da        Isoelectric Point: 5.0477

>AT128205 WP_142774357.1 NZ_CP041360:c5622300-5622085 [Spirosoma sp. KCTC 42546]
MRTNIDINDELLQVAMEISHLKTKKAIVELALQEYINMMRRKDLLSLRGKVQWDGDLDQMRTDNTPTDWDK

Download         Length: 216 bp

>AT128205 NZ_CP041360:c5622300-5622085 [Spirosoma sp. KCTC 42546]
ATGAGAACAAATATTGACATCAATGATGAGCTGCTTCAAGTAGCTATGGAAATTAGTCACCTAAAAACAAAAAAAGCGAT
CGTAGAATTGGCTTTGCAGGAGTATATCAACATGATGCGCCGTAAAGATTTGTTGTCTTTACGTGGGAAAGTTCAATGGG
ATGGTGATTTAGACCAGATGCGAACCGATAACACACCAACTGATTGGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References