Detailed information of TA system TA128204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 3621609..3622199
• Replicon: chromosome
• Accession: NZ_CP041360
• Organism: Spirosoma sp. KCTC 42546

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EXU85_RS14735
• Protein ID: WP_142772819.1
• Coordinates: 3621609..3621860 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EXU85_RS14740
• Protein ID: WP_142772820.1
• Coordinates: 3621864..3622199 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXU85_RS14725	3617016..3619538	-	2523	WP_142772817.1	DUF5686 and carboxypeptidase-like regulatory domain-containing protein	-
EXU85_RS14730	3619999..3621444	+	1446	WP_142772818.1	amidohydrolase	-
EXU85_RS14735	3621609..3621860	+	252	WP_142772819.1	type II toxin-antitoxin system HicA family toxin	Toxin
EXU85_RS14740	3621864..3622199	+	336	WP_142772820.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EXU85_RS14745	3622248..3624920	-	2673	WP_142772821.1	glucosidase	-
EXU85_RS14750	3625431..3625649	+	219	WP_142772822.1	VF530 family protein	-
EXU85_RS14755	3625744..3626979	-	1236	WP_142772823.1	TlpA family protein disulfide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-75)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9693.15 Da
• Isoelectric Point: 9.8247

>T128204 WP_142772819.1 NZ_CP041360:3621609-3621860 [Spirosoma sp. KCTC 42546]
MSEKEKLLERFQAKPTDFSWNELVSLLAYFGYEEVSKGKTEGSRRAFVNPETKKIIRLHKPHPGSILKQYQLKEIQDILN
LSN

Nucleotide

• Length: 252 bp

>T128204 NZ_CP041360:3621609-3621860 [Spirosoma sp. KCTC 42546]
ATGAGTGAAAAAGAGAAGTTACTTGAACGTTTTCAAGCGAAACCGACTGATTTTAGCTGGAATGAGTTGGTCAGTTTACT
AGCCTATTTTGGCTATGAGGAAGTTAGCAAAGGGAAAACGGAAGGTAGCCGACGAGCCTTCGTTAATCCGGAAACAAAGA
AGATTATTCGATTACATAAACCTCATCCTGGTAGTATATTAAAGCAATATCAGCTCAAAGAAATTCAGGACATACTCAAC
TTAAGCAATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12377.08 Da
• Isoelectric Point: 4.8893

>AT128204 WP_142772820.1 NZ_CP041360:3621864-3622199 [Spirosoma sp. KCTC 42546]
MENVLRYQDFVGSVQYNSDDKVFHGKLAFITDLVTFEGTSVNELESAFVEAVEDYLELCKAVGKKPEKSFAGSFNIRMQP
ELHRKAAVVSLEKGISLNQLVVEAVSKYVGQ

Nucleotide

• Length: 336 bp

>AT128204 NZ_CP041360:3621864-3622199 [Spirosoma sp. KCTC 42546]
ATGGAAAATGTACTTCGTTATCAGGATTTTGTCGGTTCCGTTCAATACAATTCCGACGATAAAGTTTTTCATGGAAAACT
TGCCTTCATAACCGACTTGGTAACATTTGAAGGAACCAGTGTCAATGAACTCGAATCCGCTTTTGTAGAAGCTGTCGAAG
ATTACCTGGAACTGTGTAAAGCGGTTGGAAAGAAGCCAGAGAAGAGTTTTGCCGGTTCATTTAATATCCGTATGCAACCC
GAATTGCATCGAAAGGCGGCAGTTGTTTCTCTCGAAAAAGGAATATCTCTGAACCAGTTAGTGGTTGAGGCTGTCAGCAA
ATATGTAGGTCAATAA