Detailed information of TA system TA128183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2181664..2182484
• Replicon: chromosome
• Accession: NZ_CP041359
• Organism: Escherichia coli strain U1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: E3Z32_RS11740
• Protein ID: WP_001550554.1
• Coordinates: 2182227..2182484 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: E3Z32_RS11735
• Protein ID: WP_001519303.1
• Coordinates: 2181664..2182215 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3Z32_RS11710	2177359..2178672	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
E3Z32_RS11715	2178684..2178962	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
E3Z32_RS11720	2178959..2180080	-	1122	WP_000010833.1	M42 family metallopeptidase	-
E3Z32_RS27405	2180325..2180441	-	117	Protein_2043	VOC family protein	-
E3Z32_RS11725	2180479..2180739	-	261	WP_000084876.1	hypothetical protein	-
E3Z32_RS11730	2180866..2181414	-	549	WP_001519301.1	hypothetical protein	-
E3Z32_RS27270	2181451..2181612	-	162	WP_001519302.1	hypothetical protein	-
E3Z32_RS11735	2181664..2182215	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
E3Z32_RS11740	2182227..2182484	-	258	WP_001550554.1	hypothetical protein	Toxin
E3Z32_RS11745	2182861..2183160	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
E3Z32_RS11750	2183223..2184464	+	1242	Protein_2050	helicase YjhR	-
E3Z32_RS11755	2185047..2186027	-	981	WP_001519307.1	transposase	-
E3Z32_RS11760	2186092..2187198	-	1107	WP_001519308.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	2181664..2193469	11805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T128183 WP_001550554.1 NZ_CP041359:c2182484-2182227 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T128183 NZ_CP041359:c2182484-2182227 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT128183 WP_001519303.1 NZ_CP041359:c2182215-2181664 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT128183 NZ_CP041359:c2182215-2181664 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8