Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 30398..30933 | Replicon | plasmid unnamed1 |
Accession | NZ_CP041358 | ||
Organism | Escherichia coli strain U1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0M1UJC2 |
Locus tag | E3Z32_RS00200 | Protein ID | WP_001270422.1 |
Coordinates | 30398..30685 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | L4J0V6 |
Locus tag | E3Z32_RS00205 | Protein ID | WP_001132895.1 |
Coordinates | 30682..30933 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3Z32_RS00170 | 25536..26705 | - | 1170 | WP_001072358.1 | hypothetical protein | - |
E3Z32_RS00175 | 27072..27260 | + | 189 | WP_001332784.1 | hypothetical protein | - |
E3Z32_RS00180 | 27381..28121 | + | 741 | WP_001066947.1 | tyrosine-type recombinase/integrase | - |
E3Z32_RS00185 | 28364..29341 | - | 978 | WP_001309253.1 | RepB family plasmid replication initiator protein | - |
E3Z32_RS00195 | 29985..30396 | - | 412 | Protein_32 | DDE-type integrase/transposase/recombinase | - |
E3Z32_RS00200 | 30398..30685 | - | 288 | WP_001270422.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E3Z32_RS00205 | 30682..30933 | - | 252 | WP_001132895.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
E3Z32_RS00215 | 31691..32896 | + | 1206 | WP_000817635.1 | AAA family ATPase | - |
E3Z32_RS00220 | 32893..33855 | + | 963 | WP_000756328.1 | ParB/RepB/Spo0J family partition protein | - |
E3Z32_RS00225 | 34089..34865 | + | 777 | Protein_37 | hypothetical protein | - |
E3Z32_RS27120 | 35032..35175 | + | 144 | WP_000270807.1 | DUF1281 domain-containing protein | - |
E3Z32_RS27125 | 35182..35541 | + | 360 | WP_001336695.1 | DUF1281 domain-containing protein | - |
E3Z32_RS00245 | 35605..35916 | + | 312 | WP_001309256.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | senB | 1..130003 | 130003 | |
- | flank | IS/Tn | - | - | 34512..34652 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11262.30 Da Isoelectric Point: 10.4703
>T128162 WP_001270422.1 NZ_CP041358:c30685-30398 [Escherichia coli]
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR
Download Length: 288 bp
>T128162 NZ_CP041358:c30685-30398 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9178.47 Da Isoelectric Point: 4.2108
>AT128162 WP_001132895.1 NZ_CP041358:c30933-30682 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL
Download Length: 252 bp
>AT128162 NZ_CP041358:c30933-30682 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M1UJC2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | L4J0V6 |