Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Xre(antitoxin) |
Location | 4467466..4468726 | Replicon | chromosome |
Accession | NZ_CP041354 | ||
Organism | Pseudomonas aeruginosa strain AZPAE15042 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A424XGP4 |
Locus tag | IHMA87_RS21445 | Protein ID | WP_074197528.1 |
Coordinates | 4467466..4468221 (-) | Length | 252 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A2R3IR82 |
Locus tag | IHMA87_RS21450 | Protein ID | WP_003157715.1 |
Coordinates | 4468358..4468726 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHMA87_RS21435 | 4464779..4465330 | + | 552 | WP_012076759.1 | AAA family ATPase | - |
IHMA87_RS21440 | 4465334..4466695 | - | 1362 | WP_079383456.1 | DNA recombination protein RmuC | - |
IHMA87_RS21445 | 4467466..4468221 | - | 756 | WP_074197528.1 | RES family NAD+ phosphorylase | Toxin |
IHMA87_RS21450 | 4468358..4468726 | - | 369 | WP_003157715.1 | DUF2384 domain-containing protein | Antitoxin |
IHMA87_RS21455 | 4468800..4470086 | - | 1287 | WP_034079451.1 | FAD-binding oxidoreductase | - |
IHMA87_RS21460 | 4470150..4471643 | - | 1494 | WP_003157849.1 | aldehyde dehydrogenase family protein | - |
IHMA87_RS21465 | 4471817..4472293 | + | 477 | WP_034079587.1 | elongation factor GreAB | - |
IHMA87_RS21470 | 4472296..4472577 | - | 282 | WP_034079448.1 | zinc ribbon domain-containing protein | - |
IHMA87_RS21475 | 4472731..4473717 | - | 987 | WP_079383452.1 | nitronate monooxygenase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28325.53 Da Isoelectric Point: 8.3280
>T128159 WP_074197528.1 NZ_CP041354:c4468221-4467466 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA
Download Length: 756 bp
>T128159 NZ_CP041354:c4468221-4467466 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTCACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTCACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13353.60 Da Isoelectric Point: 9.9874
>AT128159 WP_003157715.1 NZ_CP041354:c4468726-4468358 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
>AT128159 NZ_CP041354:c4468726-4468358 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A424XGP4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2R3IR82 |