Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4467466..4468726 Replicon chromosome
Accession NZ_CP041354
Organism Pseudomonas aeruginosa strain AZPAE15042

Toxin (Protein)


Gene name - Uniprot ID A0A424XGP4
Locus tag IHMA87_RS21445 Protein ID WP_074197528.1
Coordinates 4467466..4468221 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2R3IR82
Locus tag IHMA87_RS21450 Protein ID WP_003157715.1
Coordinates 4468358..4468726 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHMA87_RS21435 4464779..4465330 + 552 WP_012076759.1 AAA family ATPase -
IHMA87_RS21440 4465334..4466695 - 1362 WP_079383456.1 DNA recombination protein RmuC -
IHMA87_RS21445 4467466..4468221 - 756 WP_074197528.1 RES family NAD+ phosphorylase Toxin
IHMA87_RS21450 4468358..4468726 - 369 WP_003157715.1 DUF2384 domain-containing protein Antitoxin
IHMA87_RS21455 4468800..4470086 - 1287 WP_034079451.1 FAD-binding oxidoreductase -
IHMA87_RS21460 4470150..4471643 - 1494 WP_003157849.1 aldehyde dehydrogenase family protein -
IHMA87_RS21465 4471817..4472293 + 477 WP_034079587.1 elongation factor GreAB -
IHMA87_RS21470 4472296..4472577 - 282 WP_034079448.1 zinc ribbon domain-containing protein -
IHMA87_RS21475 4472731..4473717 - 987 WP_079383452.1 nitronate monooxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-205)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28325.53 Da        Isoelectric Point: 8.3280

>T128159 WP_074197528.1 NZ_CP041354:c4468221-4467466 [Pseudomonas aeruginosa]
VSEIWRLCAGEKQVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPLPESAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPGLFYAALKLETAMAEGAYYRCVLWSGMAVPPPSGRILSEHASFEAAWKVERGVRLQEPPFSDYERALTDTA
DYRVAQELGSAMRGAGVQAFEYRSARCPQRGCNVALFTPRAFIEKRPRNLTPWLCETTASYVAFKPAHVPGSPKVFAREL
FLVDGRLPQPA

Download         Length: 756 bp

>T128159 NZ_CP041354:c4468221-4467466 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTCACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13353.60 Da        Isoelectric Point: 9.9874

>AT128159 WP_003157715.1 NZ_CP041354:c4468726-4468358 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGILGVDRSAISRWKSQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDLRHFMRTPNHHLGGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT128159 NZ_CP041354:c4468726-4468358 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A424XGP4

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3IR82

References