Detailed information of TA system TA128158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3494167..3495388
• Replicon: chromosome
• Accession: NZ_CP041354
• Organism: Pseudomonas aeruginosa strain AZPAE15042

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2R3IQG1
• Locus tag: IHMA87_RS16645
• Protein ID: WP_034082650.1
• Coordinates: 3494810..3495388 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IHMA87_RS16640
• Protein ID: WP_034082653.1
• Coordinates: 3494167..3494721 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHMA87_RS16615	3489736..3490287	+	552	WP_034082661.1	XRE family transcriptional regulator	-
IHMA87_RS16620	3490284..3490682	-	399	WP_033997206.1	NADH-quinone oxidoreductase subunit A	-
IHMA87_RS16625	3490695..3491018	-	324	WP_034082658.1	quaternary ammonium compound efflux SMR transporter SugE	-
IHMA87_RS16630	3491348..3491809	+	462	WP_034082656.1	(2Fe-2S)-binding protein	-
IHMA87_RS16635	3491814..3494009	+	2196	WP_034082654.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
IHMA87_RS16640	3494167..3494721	+	555	WP_034082653.1	helix-turn-helix domain-containing protein	Antitoxin
IHMA87_RS16645	3494810..3495388	+	579	WP_034082650.1	HD domain-containing protein	Toxin
IHMA87_RS16650	3495497..3496684	-	1188	WP_012076116.1	HlyD family efflux transporter periplasmic adaptor subunit	-
IHMA87_RS16655	3496674..3498845	-	2172	WP_034082647.1	type I secretion system permease/ATPase	-
IHMA87_RS16660	3498835..3500112	-	1278	WP_003153546.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-189)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21906.80 Da
• Isoelectric Point: 5.3821

>T128158 WP_034082650.1 NZ_CP041354:3494810-3495388 [Pseudomonas aeruginosa]
MSLELLKNRLDFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAYPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T128158 NZ_CP041354:3494810-3495388 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAAGAACCGCCTCGACTTCCTCCGCGAAGCCGAACGCCTGAAAGATGTCCTGCGCTCCGCGCA
TACGTCTTCCGGTCGCCCGGAAAGCACCGCCGAACACAGTTGGCGGCTGTGCCTGATGGCGCTGGCCTTCGAGGATCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGATCTCGGCGAAGCGATCCACGGCGACATCCCG
GCCGTCGAGCAGGCCGCGTACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGTTGACTCGTCACCTCGACGC
GCCGCTGCGCGAACGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGGCCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20379.48 Da
• Isoelectric Point: 8.9546

>AT128158 WP_034082653.1 NZ_CP041354:3494167-3494721 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQAHAAELFGVAQSTISRWESGAQALRAEERTRLETLLGARLETAADRALARLVDGS
PQPMHLICDLTHRLLACSPARAAQFAVPLGDLLGRSLWPYCSEEILRQEAALDDLGWRELLAPPALEFASGTNASTIVPI
RRSRCRWTRLTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT128158 NZ_CP041354:3494167-3494721 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTTCCTTCTTCGTCCCTGGGCCCCGCCCTGCGCCGTTGGCGCCTGCTGCACCGGGTCAAGCAGGCGCA
CGCCGCCGAGCTGTTCGGCGTGGCCCAGTCGACCATCTCGCGCTGGGAATCCGGCGCCCAGGCGCTGCGGGCGGAGGAAC
GGACGCGCCTGGAAACCCTCCTCGGCGCCCGCCTGGAGACCGCCGCCGACCGGGCTCTGGCCCGCCTGGTCGATGGCAGC
CCGCAGCCGATGCATCTGATCTGCGACCTCACCCACCGCCTGCTGGCCTGCTCGCCGGCGCGCGCCGCGCAATTCGCCGT
CCCCCTCGGCGACCTGCTCGGCCGTTCGCTGTGGCCGTATTGCAGCGAGGAGATCCTCCGCCAGGAAGCCGCCCTCGACG
ACCTCGGCTGGCGCGAGCTGCTGGCGCCGCCGGCGCTGGAGTTCGCCAGCGGAACGAACGCCTCGACCATCGTGCCGATC
CGGCGCAGCCGCTGCCGCTGGACCCGCCTGACGCTCTCCGACGGCCGCGCGGTGCGGCTGGTGGAAACCCTCTGA

Structures

Toxin

• AlphaFold DB: A0A2R3IQG1