Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4718600..4719116 Replicon chromosome
Accession NZ_CP041353
Organism Klebsiella pneumoniae strain RJY9645

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag FJR44_RS22695 Protein ID WP_004894697.1
Coordinates 4718600..4718884 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FJR44_RS22700 Protein ID WP_002886901.1
Coordinates 4718874..4719116 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJR44_RS22670 4713995..4714303 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
FJR44_RS22675 4714388..4714561 + 174 WP_002886906.1 hypothetical protein -
FJR44_RS22680 4714564..4715307 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
FJR44_RS22685 4715665..4717803 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
FJR44_RS22690 4718132..4718596 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FJR44_RS22695 4718600..4718884 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJR44_RS22700 4718874..4719116 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FJR44_RS22705 4719194..4721104 - 1911 WP_065799539.1 BglG family transcription antiterminator -
FJR44_RS22710 4721127..4722281 - 1155 WP_004178372.1 lactonase family protein -
FJR44_RS22715 4722348..4723088 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T128152 WP_004894697.1 NZ_CP041353:c4718884-4718600 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T128152 NZ_CP041353:c4718884-4718600 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTATGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT128152 WP_002886901.1 NZ_CP041353:c4719116-4718874 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT128152 NZ_CP041353:c4719116-4718874 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References