Detailed information of TA system TA128151

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4648730..4649422
• Replicon: chromosome
• Accession: NZ_CP041353
• Organism: Klebsiella pneumoniae strain RJY9645

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FJR44_RS22385
• Protein ID: WP_172402701.1
• Coordinates: 4648730..4649044 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FJR44_RS22390
• Protein ID: WP_172402700.1
• Coordinates: 4649087..4649422 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJR44_RS22355	4644545..4645672	+	1128	WP_023325431.1	PAAR domain-containing protein	-
FJR44_RS22360	4645662..4645925	+	264	WP_004192273.1	hypothetical protein	-
FJR44_RS22365	4646071..4646205	+	135	Protein_4385	transposase	-
FJR44_RS22370	4646218..4646328	-	111	Protein_4386	DUF4102 domain-containing protein	-
FJR44_RS22375	4646703..4647710	-	1008	WP_040148942.1	restriction endonuclease	-
FJR44_RS22380	4647787..4648617	-	831	WP_040148943.1	DUF4942 domain-containing protein	-
FJR44_RS22385	4648730..4649044	-	315	WP_172402701.1	TA system toxin CbtA family protein	Toxin
FJR44_RS22390	4649087..4649422	-	336	WP_172402700.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FJR44_RS22395	4649423..4649893	-	471	WP_065799537.1	DNA repair protein RadC	-
FJR44_RS22400	4649964..4650785	-	822	WP_040148947.1	DUF945 domain-containing protein	-
FJR44_RS22405	4650884..4651096	-	213	WP_040148948.1	hypothetical protein	-
FJR44_RS22410	4651170..4651451	-	282	Protein_4394	hypothetical protein	-
FJR44_RS22415	4651599..4652063	-	465	WP_040148963.1	hypothetical protein	-
FJR44_RS22420	4652935..4654389	+	1455	WP_072042785.1	DUF3987 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4640418..4666571	26153

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (6-103)

Antitoxin

• Antitoxin CbeA (12-110)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11821.33 Da
• Isoelectric Point: 6.4783

>T128151 WP_172402701.1 NZ_CP041353:c4649044-4648730 [Klebsiella pneumoniae]
ISTVPAKESVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHNDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGFTW
QDQTPFLTTTDILRARRATGIINT

Nucleotide

• Length: 315 bp

>T128151 NZ_CP041353:c4649044-4648730 [Klebsiella pneumoniae]
ATTTCAACTGTACCGGCCAAGGAGTCGGTTTCGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAACGTATCT
GCTGAATCACCATTACGGCCTGACGCTTAACGACACGCCATTCCATAACGACACGGCCATTCAGGAGCATATTGAAGCTG
GTATTGCACTTGCTGATGCAGTGAATTTCCTGGTGGAACGCTATGAACTGGTACGCACTGACCGTAAGGGATTCACTTGG
CAAGATCAGACACCATTCCTGACCACCACCGATATTCTCAGAGCCAGACGAGCTACCGGAATAATAAATACTTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12458.29 Da
• Isoelectric Point: 6.4455

>AT128151 WP_172402700.1 NZ_CP041353:c4649422-4649087 [Klebsiella pneumoniae]
MEVFMPFTLPNEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLAQTFPLFISQLEAMLRSGELNSQQQ
HQVTIQLASLTCIADTRGSCGYVYISIYPTP

Nucleotide

• Length: 336 bp

>AT128151 NZ_CP041353:c4649422-4649087 [Klebsiella pneumoniae]
ATGGAGGTTTTCATGCCATTCACACTACCCAATGAATGGGGGCTACAAAGCGATATCACCCCACGATTTGGCGCAAGATT
AGTTCAGGAAGGCAACCGGCTGCATTACCTGGCTGACAGGGCTGGTTTGACGGGGGAAATTACCCCGAAGCAACTGCAGA
AACTGGCTCAAACTTTCCCGCTGTTTATCAGTCAATTGGAAGCAATGCTGCGCTCCGGTGAGCTAAATTCACAGCAGCAA
CATCAGGTGACCATTCAACTTGCGAGTCTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTAT
TTATCCAACCCCTTAA