Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4011618..4012237 Replicon chromosome
Accession NZ_CP041353
Organism Klebsiella pneumoniae strain RJY9645

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FJR44_RS19330 Protein ID WP_002892050.1
Coordinates 4012019..4012237 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FJR44_RS19325 Protein ID WP_002892066.1
Coordinates 4011618..4011992 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJR44_RS19315 4006770..4007963 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FJR44_RS19320 4007986..4011132 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FJR44_RS19325 4011618..4011992 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FJR44_RS19330 4012019..4012237 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FJR44_RS19335 4012396..4012962 + 567 WP_002892030.1 maltose O-acetyltransferase -
FJR44_RS19340 4012934..4013074 - 141 WP_032409038.1 hypothetical protein -
FJR44_RS19345 4013095..4013565 + 471 WP_002892026.1 YlaC family protein -
FJR44_RS19350 4013540..4014991 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FJR44_RS19355 4015092..4015790 + 699 WP_004893822.1 GNAT family N-acetyltransferase -
FJR44_RS19360 4015787..4015927 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FJR44_RS19365 4015927..4016190 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T128149 WP_002892050.1 NZ_CP041353:4012019-4012237 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T128149 NZ_CP041353:4012019-4012237 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT128149 WP_002892066.1 NZ_CP041353:4011618-4011992 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT128149 NZ_CP041353:4011618-4011992 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References