Detailed information of TA system TA128133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-yafN/ParE-YafN
• Location: 2715322..2715847
• Replicon: chromosome
• Accession: NZ_CP041352
• Organism: Casimicrobium huifangae strain SJ-1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: FKL89_RS12245
• Protein ID: WP_156863021.1
• Coordinates: 2715563..2715847 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: yafN
• Uniprot ID: -
• Locus tag: FKL89_RS12240
• Protein ID: WP_156863020.1
• Coordinates: 2715322..2715573 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKL89_RS12215	2711224..2712513	+	1290	WP_156863015.1	adenylosuccinate synthase	-
FKL89_RS12220	2712900..2713412	+	513	WP_156863016.1	phosphoribosyltransferase	-
FKL89_RS12225	2713474..2713896	+	423	WP_156863017.1	DUF3052 family protein	-
FKL89_RS12230	2713949..2714596	+	648	WP_156863018.1	glutathione S-transferase family protein	-
FKL89_RS12235	2714660..2715238	+	579	WP_156863019.1	hypothetical protein	-
FKL89_RS12240	2715322..2715573	+	252	WP_156863020.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FKL89_RS12245	2715563..2715847	+	285	WP_156863021.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FKL89_RS12250	2716144..2716659	+	516	WP_156863022.1	hypothetical protein	-
FKL89_RS12255	2716981..2718087	+	1107	WP_156864682.1	alpha/beta fold hydrolase	-
FKL89_RS12260	2718084..2719853	-	1770	WP_162527506.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-71)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11090.86 Da
• Isoelectric Point: 9.9156

>T128133 WP_156863021.1 NZ_CP041352:2715563-2715847 [Casimicrobium huifangae]
MTYELAIHPLAEAEWKRLDESVKRRFKQKLAKERLTNPRVAKDALHGEPDCYKIKITTPQYRLAYHVDDKVRLLTILAVS
SRDDVYELLQARRP

Nucleotide

• Length: 285 bp

>T128133 NZ_CP041352:2715563-2715847 [Casimicrobium huifangae]
ATGACCTATGAGCTTGCGATCCATCCGCTAGCCGAAGCGGAATGGAAGCGCCTTGACGAATCTGTAAAGCGCCGCTTCAA
GCAAAAGCTGGCGAAGGAACGGCTGACAAATCCGCGTGTCGCCAAGGACGCTCTGCACGGTGAACCTGATTGTTACAAGA
TAAAAATCACCACACCGCAATATCGACTCGCATATCACGTCGATGACAAGGTGCGGCTACTCACGATTCTCGCTGTCAGT
TCGCGTGACGACGTTTACGAATTGCTGCAGGCGCGACGCCCGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9052.34 Da
• Isoelectric Point: 7.0113

>AT128133 WP_156863020.1 NZ_CP041352:2715322-2715573 [Casimicrobium huifangae]
MDTLLSTRSIGISDLRESPARAFEQADETAVVVLNHNRPAGYILSTRLMEALLDQAADRLITSRAAARVASIKSARKITL
DDL

Nucleotide

• Length: 252 bp

>AT128133 NZ_CP041352:2715322-2715573 [Casimicrobium huifangae]
ATGGACACTCTTCTTTCCACCCGCAGCATTGGCATCTCCGATTTGCGCGAATCACCGGCTCGTGCTTTCGAGCAGGCCGA
CGAAACGGCTGTGGTTGTGCTCAATCACAATCGGCCTGCGGGTTACATCCTGTCCACGCGTCTGATGGAAGCGTTGCTTG
ATCAGGCGGCTGATCGTTTGATCACGTCAAGGGCAGCGGCGCGCGTGGCGTCCATCAAGAGTGCGCGCAAAATCACGCTC
GATGACCTATGA