Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 443310..443948 Replicon chromosome
Accession NZ_CP041352
Organism Casimicrobium huifangae strain SJ-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FKL89_RS02030 Protein ID WP_156861058.1
Coordinates 443541..443948 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag FKL89_RS02025 Protein ID WP_156861057.1
Coordinates 443310..443540 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKL89_RS02000 438824..439207 + 384 WP_156861053.1 ATP-binding protein -
FKL89_RS02005 439238..440448 + 1211 WP_156860844.1 IS3 family transposase -
FKL89_RS02010 440450..441742 + 1293 WP_156861054.1 AAA family ATPase -
FKL89_RS02015 441782..442357 + 576 WP_156861055.1 isochorismatase family protein -
FKL89_RS02020 442435..443160 - 726 WP_156861056.1 nitroreductase -
FKL89_RS02025 443310..443540 + 231 WP_156861057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FKL89_RS02030 443541..443948 + 408 WP_156861058.1 type II toxin-antitoxin system VapC family toxin Toxin
FKL89_RS02035 444027..445613 - 1587 WP_156861059.1 gamma-glutamyltransferase family protein -
FKL89_RS02040 445723..447618 - 1896 WP_156861060.1 hypothetical protein -
FKL89_RS02045 447642..448313 - 672 WP_156861061.1 response regulator transcription factor -
FKL89_RS02050 448544..448870 + 327 WP_156861062.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15006.15 Da        Isoelectric Point: 7.4750

>T128129 WP_156861058.1 NZ_CP041352:443541-443948 [Casimicrobium huifangae]
MGVRYLLDTNICIYIAKHNPPNVRARFAAHAADALAMSVITFGELQHGAEKSQIRTRSLDALHQLVTLIQVMPLTEAAGR
HYGEIRVALERAGQPIGNNDLWIAAHARAEGWVLVTNNEREFRRVEGLAVENWAA

Download         Length: 408 bp

>T128129 NZ_CP041352:443541-443948 [Casimicrobium huifangae]
ATGGGTGTTCGCTACCTGCTGGACACCAATATCTGCATTTACATCGCGAAGCACAATCCCCCGAATGTTCGAGCGCGCTT
CGCAGCGCATGCGGCTGATGCGCTCGCAATGTCGGTCATTACATTCGGCGAACTTCAGCACGGCGCAGAAAAGAGCCAGA
TCCGAACGCGATCACTCGACGCACTCCATCAGCTGGTGACGCTGATTCAGGTGATGCCACTCACTGAGGCAGCCGGCCGG
CACTATGGCGAGATTCGCGTCGCGCTGGAGCGGGCCGGGCAGCCAATCGGCAACAACGATCTGTGGATCGCCGCCCATGC
TCGTGCGGAGGGCTGGGTACTGGTGACCAACAACGAGCGCGAATTTCGCCGGGTTGAAGGTCTGGCGGTGGAGAACTGGG
CCGCTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8599.75 Da        Isoelectric Point: 5.0790

>AT128129 WP_156861057.1 NZ_CP041352:443310-443540 [Casimicrobium huifangae]
MTIARIFQSGNSQAVRLPKEFRFKSDRVEIFRKGDDIILRERPATGAVIFDALAEFPDDFMADGRADTPPQTREGL

Download         Length: 231 bp

>AT128129 NZ_CP041352:443310-443540 [Casimicrobium huifangae]
ATGACCATCGCTCGCATCTTCCAGTCTGGCAACAGTCAGGCGGTGCGTTTGCCGAAGGAATTCCGGTTCAAGTCGGATCG
CGTTGAGATTTTCCGAAAAGGCGACGACATCATCTTGCGCGAACGGCCCGCTACTGGGGCCGTGATATTCGATGCGCTGG
CTGAGTTCCCAGACGACTTCATGGCCGATGGGCGCGCGGATACGCCGCCGCAGACGCGCGAGGGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References