Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 28474..29109 Replicon plasmid pB
Accession NZ_CP041350
Organism Komagataeibacter xylinus strain CGMCC 17276

Toxin (Protein)


Gene name vapC Uniprot ID A0A850P7P3
Locus tag FMA36_RS18130 Protein ID WP_061276389.1
Coordinates 28699..29109 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0N1FCF7
Locus tag FMA36_RS18125 Protein ID WP_025440224.1
Coordinates 28474..28698 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMA36_RS18095 23859..24842 - 984 Protein_23 aldo/keto reductase -
FMA36_RS18100 25049..25818 - 770 Protein_24 alpha/beta hydrolase -
FMA36_RS18105 25911..26229 - 319 Protein_25 WHG domain-containing protein -
FMA36_RS18110 26314..27750 + 1437 WP_061276393.1 Si-specific NAD(P)(+) transhydrogenase -
FMA36_RS18115 27866..28105 + 240 Protein_27 transposase domain-containing protein -
FMA36_RS18120 28099..28365 + 267 Protein_28 IS3 family transposase -
FMA36_RS18125 28474..28698 + 225 WP_025440224.1 hypothetical protein Antitoxin
FMA36_RS18130 28699..29109 + 411 WP_061276389.1 type II toxin-antitoxin system VapC family toxin Toxin
FMA36_RS18135 29468..30838 + 1371 WP_130732834.1 hypothetical protein -
FMA36_RS18140 31123..31398 + 276 WP_025829448.1 formaldehyde-responsive transcriptional repressor FrmR -
FMA36_RS18145 31440..32549 + 1110 WP_039733241.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
FMA36_RS18150 32609..33010 + 402 WP_039733238.1 VOC family protein -
FMA36_RS18155 33035..33862 + 828 WP_039733239.1 S-formylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190752 190752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15520.70 Da        Isoelectric Point: 6.0937

>T128127 WP_061276389.1 NZ_CP041350:28699-29109 [Komagataeibacter xylinus]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVHTRREVEHFAARLAVLPFDSEAAAHT
ADIRAALERNGRIIDPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Download         Length: 411 bp

>T128127 NZ_CP041350:28699-29109 [Komagataeibacter xylinus]
ATGCTGCGTTACCTGCTGGATACGAACCTCTGTATCCGGGTGTTGCGGGATCGACCGCAGGGGCTGCGTCCGAGGTTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTGCTGTATGAGCTGCTTTATGGCGCGGAACGCTCGTCTGATCCCG
TGCACACAAGGCGTGAGGTCGAGCACTTCGCGGCAAGGCTGGCGGTCCTGCCATTCGACAGTGAAGCGGCCGCCCATACA
GCGGACATTCGGGCTGCTCTTGAACGGAATGGCCGTATCATAGATCCGTATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGGGGGCTGATTGTGGTGACCGGCAATCTGCGGGAATTTCAGCGGGTGGAAGGTCTTCGAACCGAGGACTGGTTGACTG
ACACGGTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8297.56 Da        Isoelectric Point: 5.0001

>AT128127 WP_025440224.1 NZ_CP041350:28474-28698 [Komagataeibacter xylinus]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVREVVIVSEGPRRIIAPVDVAWDDFFAAPGVDLGERNQPAMQEREAL

Download         Length: 225 bp

>AT128127 NZ_CP041350:28474-28698 [Komagataeibacter xylinus]
ATGCTGACCCGCACAACACTCTTTCTATCCAATCGCTCGCAGGCGGTGCGTCTGCCGAAGATGGTCGCCTTCGGGGAACA
GGTGCGTGAGGTGGTCATCGTGTCCGAAGGTCCACGGCGGATCATCGCTCCGGTCGATGTGGCGTGGGATGATTTCTTTG
CGGCTCCCGGGGTGGATCTGGGGGAGCGGAACCAGCCAGCCATGCAGGAACGCGAGGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A850P7P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1FCF7

References